CD2 Protein & Antibody

Cluster of Differentiation 2

CD2 Products

CD2 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD2	Human	CD2 Protein, Recombinant	10982-H08H
CD2	Mouse	CD2 Protein, Recombinant	50537-M08H

CD2 Antibody

Molecule	Application	Description	Cat. No
Human CD2	WB, ELISA	CD2 Antibody, Mouse MAb	10982-MM06
Mouse CD2	WB, ELISA	CD2 Antibody, Rabbit PAb	50537-RP01
Mouse CD2	WB, ELISA	CD2 Antibody, Rabbit PAb (Antigen Affinity Purified)	50537-RP02

CD2 cDNA Clone

Molecule	Species	Description	Cat. No
CD2	Human	Homo sapiens CD2 cDNA Clone(NM_001767.3)	HG10982-M
CD2	Mouse	Mus musculus CD2 cDNA Clone	MG50537-M
CD2	Rat	Rat CD2 cDNA Clone	RG80223-G

CD2 Related Areas

Cancer>>Cancer Stem Cell (CSC)>>CD2

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>>CD2

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD2

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Migration/Adhesion>>CD2

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>CD2

CD2 Alternative Names

CD2, RP4-655N15.2, FLJ46032, SRBC, T11 [Homo sapiens]

Cd2, LFA-2, Ly-37, Ly37 [Mus musculus]

CD2 Background

T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). CD2 has been shown to set quantitative thresholds in T cell activation both in vivo and in vitro. Further, intracellular CD2 signaling pathways and networks are being discovered by the identification of several cytosolic tail binding proteins. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. As a cell surface glycoprotein, CD2 expressed on most human T cells and natural killer (NK) cells and plays an important role in mediating cell adhesion in both T-lymphocytes and in signal transduction.

CD2 Related Studies

1. Yang JJ, et al. (2001) Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Curr Protein Pept Sci. 2(1): 1-17.
2. Wilkins AL, et al. (2003) Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design. Curr Protein Pept Sci. 4(5): 367-73.
3. McNerney ME, et al. (2006) The CD2 family of natural killer cell receptors. Curr Top Microbiol Immunol. 298: 91-120.