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CD2  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
  • Slide 1
10982-H08H-20
10982-H08H-10
20 µg 
10 µg 
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Expression host: Human Cells  
  • Slide 1
50537-M08H-50
50537-M08H-20
50 µg 
20 µg 
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Expression host: Human Cells  
  • Slide 1
80158-R02H-20
80158-R02H-100
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
90300-C02H-20
90300-C02H-100
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
90300-C08H-20
90300-C08H-100
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
70107-D02H-20
70107-D02H-100
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
70107-D08H-20
70107-D08H-100
20 µg 
100 µg 
Add to Cart

CD2 Related Area

CD2 Related Pathways

    CD2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CD2 Summary & Protein Information

    CD2 Background

    Gene Summary: CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it
    General information above from NCBI
    Subunit structure: Interacts with CD2AP (By similarity). Interacts with PSTPIP1.
    Subcellular location: Membrane; Single-pass type I membrane protein.
    Sequence similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    General information above from UniProt

    T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). CD2 has been shown to set quantitative thresholds in T cell activation both in vivo and in vitro. Further, intracellular CD2 signaling pathways and networks are being discovered by the identification of several cytosolic tail binding proteins. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. As a cell surface glycoprotein, CD2 expressed on most human T cells and natural killer (NK) cells and plays an important role in mediating cell adhesion in both T-lymphocytes and in signal transduction.

    CD2 Alternative Name

    T11,SRBC,LFA-2, [homo-sapiens]
    RP4-655N15.2,SRBC,T11,CD2,FLJ46032, [human]
    Cd2,LFA-2,Ly37,Ly-37, [mouse]
    Ly37,LFA-2,Ly-37, [mus-musculus]

    CD2 Related Studies

  • Yang JJ, et al. (2001) Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Curr Protein Pept Sci. 2(1): 1-17.
  • Wilkins AL, et al. (2003) Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design. Curr Protein Pept Sci. 4(5): 367-73.
  • McNerney ME, et al. (2006) The CD2 family of natural killer cell receptors. Curr Top Microbiol Immunol. 298: 91-120.
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