Anti-CD2 Antibody

Cat: 10982-RP02
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All CD2 Reagents
Anti-CD2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD2 Antibody
Validated applications
WB,ELISA
Species reactivity
Reacts with: Human
Specificity
Human CD2
Immunogen
Recombinant Human CD2 protein (Catalog#10982-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CD2 (rh CD2; Catalog#10982-H08H; NP_001758.2; Met 1-Asp 209). CD2 specific IgG was purified by Human CD2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD2 Antibody (Rabbit Polyclonal antibody) Images
Human CD2 Western blot (WB) 13315

Anti-CD2 rabbit polyclonal antibody at 1:500 dilution

Lane A: Jurkat Membrane Lysate

Lane B: MOLt-4 Membrane Lysate

Lysates/proteins at 20 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:39 kDa

Observed band size:52 kDa

Anti-CD2 Antibody Alternative Names
Anti-LFA-2 Antibody;Anti-SRBC Antibody;Anti-T11 Antibody
CD2 Background Information

T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). CD2 has been shown to set quantitative thresholds in T cell activation both in vivo and in vitro. Further, intracellular CD2 signaling pathways and networks are being discovered by the identification of several cytosolic tail binding proteins. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. As a cell surface glycoprotein, CD2 expressed on most human T cells and natural killer (NK) cells and plays an important role in mediating cell adhesion in both T-lymphocytes and in signal transduction.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD2 molecule
References
  • Yang JJ, et al. (2001) Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Curr Protein Pept Sci. 2(1): 1-17.
  • Wilkins AL, et al. (2003) Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design. Curr Protein Pept Sci. 4(5): 367-73.
  • McNerney ME, et al. (2006) The CD2 family of natural killer cell receptors. Curr Top Microbiol Immunol. 298: 91-120.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD2 Antibody Rabbit Monoclonal ELISA,IHC-P 50537-R029
    Anti-CD2 Antibody Rabbit Polyclonal WB,ELISA 50537-RP02
    Anti-CD2 Antibody Rabbit Polyclonal WB 50537-T32
    Anti-CD2 Antibody Rabbit Polyclonal ELISA 50537-RP01
    Anti-CD2 Antibody Rabbit Monoclonal ELISA 10982-R224
    Anti-CD2 Antibody Rabbit Polyclonal ELISA 10982-T16
    Anti-CD2 Antibody Mouse Monoclonal ELISA 10982-MM06
    Anti-CD2 Antibody Rabbit Polyclonal ELISA 10982-RP01
    Anti-CD2 Antibody (PE) Rabbit Monoclonal FCM 10982-R118-P
    Anti-CD2 Antibody (FITC) Rabbit Monoclonal FCM 10982-R118-F
    Anti-CD2 Antibody (PerCP) Rabbit Monoclonal FCM 10982-R118-C
    Anti-CD2 Antibody Mouse Monoclonal ELISA 10982-MM02
    Anti-CD2 Antibody (APC) Rabbit Monoclonal FCM 10982-R118-A
    Anti-CD2 Antibody Rabbit Monoclonal FCM 10982-R118
    Anti-CD2 Antibody (FITC) Mouse Monoclonal FCM 10982-M127-F
    Anti-CD2 Antibody (PerCP) Mouse Monoclonal FCM 10982-M127-C
    Anti-CD2 Antibody Mouse Monoclonal IHC-P 10982-MM05
    Anti-CD2 Antibody (APC) Mouse Monoclonal FCM 10982-M127-A
    Anti-CD2 Antibody Mouse Monoclonal FCM 10982-M127
    Anti-CD2 Antibody (PE) Mouse Monoclonal FCM 10982-M127-P
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