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CD19  Antibody

All CD19 Reagents

Reactivity: Human  
Application: ELISA  IP  
11880-R303-50
11880-R303-100
50 µg 
100 µg 
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  • Slide 1
Reactivity: Human  
Application: FCM  
11880-MM17-F-25
11880-MM17-F-100
25 Test 
100 Tests 
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  • Slide 1
Reactivity: Human  
Application: ELISA  
11880-MM05-50
11880-MM05-200
11880-MM05-100
50 µg 
200 µg 
100 µg 
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    Reactivity: Human  
    Application: FCM  
    11880-MM17-50
    11880-MM17-200
    11880-MM17-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    • Slide 1
    Reactivity: Human  
    Application: FCM  
    11880-MM17-P-25
    11880-MM17-P-100
    25 Test 
    100 Tests 
    Add to Cart
    • Slide 1
    Reactivity: Human  
    Application: ELISA  IP  
    11880-R410-50
    11880-R410-100
    50 µg 
    100 µg 
    Add to Cart
    • Slide 1
    Reactivity: Human  
    Application: 
    11880-MM02-50
    11880-MM02-200
    11880-MM02-100
    11880-MM02-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
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      Reactivity: Human  
      Application: IHC-P  
      11880-R109-50
      11880-R109-100
      50 µg 
      100 µg 
      Add to Cart
      • Slide 1
      • Slide 1
      Reactivity: Human  
      Application: ELISA  
      11880-RP01-400
      11880-RP01-200
      11880-RP01-100
      400 µg 
      200 µg 
      100 µg 
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        Reactivity: Human  
        Application: 
        11880-MM15-50
        11880-MM15-200
        11880-MM15-100
        11880-MM15-1
        50 µg 
        200 µg 
        100 µg 
        1 mg 
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          CD19 Related Area

          CD19 Related Pathways

            CD19 Summary & Protein Information

            CD19 Background

            Gene Summary: Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. CD19 gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
            General information above from NCBI
            Subunit structure: Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN. {ECO:0000269|PubMed:10706702, ECO:0000269|PubMed:7687428}.
            Subcellular location: Membrane; Single-pass type I membrane protein.
            Post-translational: Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. {ECO:0000269|PubMed:10706702, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:7687539}.
            Involvement in disease: DISEASE: Immunodeficiency, common variable, 3 (CVID3) [MIM:613493]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269|PubMed:16672701}. Note=The disease is caused by mutations affecting the gene represented in this entry.
            Sequence similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
            General information above from UniProt

            The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 19 (CD19) is a member of CD system. CD19 is a cell surface molecule that assembles with the antigen receptor of B-cells. This results in a descent in threshold for antigen receptor-dependent stimulation. A simplified view holds that the ability of B-cells to respond to the various antigens in a specific and sensitive manner is achieved in the presence of low-affinity antigen receptors. CD19 primarily acts as a B-cell coreceptor in conjunction with CD21 and CD81. The formation of the receptor complex is induced by antigen and CD19, induced by exogenous antigen, has been found cytoplasmic tail phosphorylated and bind to sIg.

            Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

            CD19 Alternative Name

            CVID3, []
            B4,CVID3, [homo-sapiens]
            B4,CD19,MGC12802, [human]
            AW495831,Cd19, [mouse]
            AW495831, [mus-musculus]

            CD19 Related Studies

          • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
          • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
          • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
          • Carter RH, et al. (1992) CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science. 256 (5053): 105-7.
          • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"