CD19 Protein

Cluster of Differentiation 19

CD19 Products

CD19 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD19	Human	CD19 Protein, Recombinant	11880-H08H
CD19	Mouse	CD19 Protein, Recombinant	50510-M08H

  11880-H08H: Immobilized human CD19 at 2 µg/ml (100 µl/well) can bind biotinylated human CD9 with a linear ranger of 0.032-0.8 µg/ml. Measured by its binding ability in a functional ELISA.

  50510-M08H: Immobilized mouse CD19 at 20 µg/ml (100 µl/well) can bind biotinylated human CD9 with a linear ranger of 0.032-0.8 µg/ml. Measured by its binding ability in a functional ELISA.

CD19 cDNA Clonne

Molecule	Species	Description	Cat. No
CD19	Mouse	CD19 cDNA Clone / ORF Clone	MG50510-M
CD19	Cynomolgus	CD19 cDNA Clone / ORF Clone	KG90051-G

CD19 Related Areas

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD19

CD19 Alternative Names

CD19, B4, MGC12802 [Homo sapiens]

Cd19, AW495831 [Mus musculus]

CD19 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 19 (CD19) is a member of CD system. CD19 is a cell surface molecule that assembles with the antigen receptor of B-cells. This results in a descent in threshold for antigen receptor-dependent stimulation. A simplified view holds that the ability of B-cells to respond to the various antigens in a specific and sensitive manner is achieved in the presence of low-affinity antigen receptors. CD19 primarily acts as a B-cell coreceptor in conjunction with CD21 and CD81. The formation of the receptor complex is induced by antigen and CD19, induced by exogenous antigen, has been found cytoplasmic tail phosphorylated and bind to sIg.

CD19 Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
4. Carter RH, et al. (1992) CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes.  Science. 256 (5053): 105-7.