All RP105 reagents are produced in house and quality controlled, including 2 RP105 Antibody, 36 RP105 Gene, 3 RP105 Lysate, 3 RP105 Protein, 2 RP105 qPCR. All RP105 reagents are ready to use.
Recombinant RP105 proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc.
RP105antibodies are validated with different applications, which are ELISA, IHC-P, WB.
RP105cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each RP105 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD180, also known as RP105, is a B-cell surface molecule belonging to the family of pathogen receptors, Toll-like receptors (TLR). CD180 has an extracellular leucine-rich repeats and a short cytoplasmic tail. CD180 / RP105 interact with an extracellular molecule named MD1 and then together form the cell surface receptor complex RP105 / MD1 which induces B-cell activation in humans and mice, leading to proliferation and up-regulation of a costimulatory molecule, B7.2 / CD86. CD180 / RP105 also has a role in LPS response because B cells lacking RP105 show hyporesponsiveness to LPS.