CD180 / RP105 Protein

Cluster of Differentiation 180 / Radioprotective 105 kDa protein

CD180 / RP105 Products

CD180 / RP105 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD180/RP105	Human	CD180/RP105 Protein, Recombinant	11370-H08H
CD180/RP105	Mouse	CD180/RP105/Fc Protein, Recombinant	50491-M02H
CD180/RP105	Mouse	CD180/RP105 Protein, Recombinant	50491-M08H

  11370-H08H: Immobilized human CD180 at 2 μg/ml (100 μl/well) can bind biotinylated mouse MD-1 with a linear ranger of  3.125 - 25 ug/ml. Measured by its binding ability in a functional ELISA.

  50491-M08H: Immobilized mouse CD180 at 2 μg/ml (100 μl/well) can bind biotinylated mouse MD-1 with a linear ranger of  6.25  -  50 μg/ml. Measured by its binding ability in a functional ELISA.

CD180 / RP105 cDNA Clone

Molecule	Species	Description	Cat. No
CD180/RP105	Human	Homo sapiens CD180/RP105 cDNA Clone	HG11370-M
CD180/RP105	Mouse	Mus musculus CD180/RP105 cDNA Clone	MG50491-M

CD180 / RP105 Related Areas

Immunology>>Innate Immunity>>Toll-like Receptor>>CD180/RP105

Immunology>>Cluster of Differentiation>>CD180/RP105

CD180 / RP105 Alternative Names

CD180, RP105, LY64, Ly78, MGC126233, MGC126234 [Homo sapiens]

Cd180, RP105, F630107B15, Ly78 [Mus musculus]

CD180 / RP105 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD180, also known as RP105, is a B-cell surface molecule belonging to the family of pathogen receptors, Toll-like receptors (TLR). CD180 has an extracellular leucine-rich repeats and a short cytoplasmic tail. CD180 / RP105 interact with an extracellular molecule named MD1 and then together form the cell surface receptor complex RP105 / MD1 which induces B-cell activation in humans and mice, leading to proliferation and up-regulation of a costimulatory molecule, B7.2 / CD86. CD180 / RP105 also has a role in LPS response because B cells lacking RP105 show hyporesponsiveness to LPS.

CD180 / RP105 Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
4. Nagai Y, et al. (2002) Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide. Journal of the American society of hematology. 99(5): 1699-705.