Anti-CD16a Antibody

Cat: 80017-MM06
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All CD16a Reagents
Anti-CD16a Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-CD16a Antibody
Validated applications
Species reactivity
Reacts with: Rat
Rat CD16a
No cross-reactivity with Human cell lysate (293 cell line) in ELISA
Recombinant Rat CD16a / FCGR3A Protein (Catalog#80017-R08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat CD16a / FCGR3A (rR CD16a / FCGR3A; Catalog #80017-R08H; Met 1-Pro 200; ABO70343.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG1 Clone #4B1H6
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD16a Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

CD16a Background Information

The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells.

CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.

Full Name
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
  • David Dornan, et al. Effect of FCGR2A and FCGR3A variants on CLL outcome. Blood. 2010 116: 4212-4222
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD16a Antibody Rabbit Monoclonal ELISA 80017-R041
    Anti-CD16a Antibody Rabbit Polyclonal ELISA 80017-RP01
    Anti-CD16a Antibody Rabbit Polyclonal WB,ELISA,IP 80017-RP02
    Anti-CD16a Antibody Rabbit Polyclonal ELISA 10389-RP01
    Anti-CD16a Antibody Rabbit Polyclonal ELISA 10389-RP02
    Anti-CD16a Antibody Mouse Monoclonal ELISA 10389-MM02
    Anti-CD16a Antibody Mouse Monoclonal IHC-P 10389-MM04
    Anti-CD16a Antibody Mouse Monoclonal ELISA 10389-MM03
    Anti-CD16a Antibody Rabbit Polyclonal ELISA,IHC-P 10389-T24
    Anti-CD16a Antibody Mouse Monoclonal ELISA 10389-MM05
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