Anti-CD16a Antibody

Cat: 10389-RP02
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All CD16a Reagents
Anti-CD16a Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD16a Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CD16a
Immunogen
Recombinant Human CD16a protein (Catalog#10389-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CD16a (rh CD16a; Catalog#10389-H08H; NP_001121068.1; Met 1-Gln 208). CD16a specific IgG was purified by human CD16a affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD16a Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD16a Antibody Alternative Names
Anti-CD16 Antibody;Anti-CD16A Antibody;Anti-Fc gamma RIIIa Antibody;Anti-FCG3 Antibody;Anti-FCGR3 Antibody;Anti-FCGRIII Antibody;Anti-FCR-10 Antibody;Anti-FCRIII Antibody;Anti-FCRIIIA Antibody;Anti-IGFR3 Antibody;Anti-IMD20 Antibody
CD16a Background Information

The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells.

CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.

Full Name
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
References
  • David Dornan, et al. Effect of FCGR2A and FCGR3A variants on CLL outcome. Blood. 2010 116: 4212-4222
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD16a Antibody Rabbit Monoclonal ELISA 80017-R041
    Anti-CD16a Antibody Rabbit Polyclonal ELISA 80017-RP01
    Anti-CD16a Antibody Mouse Monoclonal ELISA 80017-MM06
    Anti-CD16a Antibody Rabbit Polyclonal WB,ELISA,IP 80017-RP02
    Anti-CD16a Antibody Mouse Monoclonal ELISA 10389-MM02
    Anti-CD16a Antibody Mouse Monoclonal IHC-P 10389-MM04
    Anti-CD16a Antibody Rabbit Polyclonal ELISA 10389-RP01
    Anti-CD16a Antibody Mouse Monoclonal ELISA 10389-MM03
    Anti-CD16a Antibody Rabbit Polyclonal ELISA,IHC-P 10389-T24
    Anti-CD16a Antibody Mouse Monoclonal ELISA 10389-MM05
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