Anti-CD166 / ALCAM Antibody

Cat: 10045-MM05
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All CD166 / ALCAM Reagents
Anti-CD166 / ALCAM Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-CD166 / ALCAM Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CD166 / ALCAM
No cross-reactivity in ELISA with Human BCAM Human CD146 Human CD171 Human EpCAM Human cell lysate (293 cell line)
Immunogen
Recombinant Human CD166 / ALCAM Protein (Catalog#10045-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD166 / ALCAM (rh CD166 / ALCAM; Catalog#10045-H08H; NP_001618.2; Met 1-Ala 526). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #6E3C7
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD166 / ALCAM Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD166 / ALCAM Antibody Alternative Names
Anti-CD166 Antibody;Anti-MEMD Antibody
CD166 / ALCAM Background Information

Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. The extracellular domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains), of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Recently, homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression. And CD166 is regarded as a potential novel breast cancer indicator and therapeutic target.

Full Name
activated leukocyte cell adhesion molecule
References
  • Swart GW. (2002) Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell migration. Eur J Cell Biol. 81(6): 313-21.
  • Fujiwara H, et al. (2003) Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166). J Clin Endocrinol Metab. 88(7): 3437-43.
  • Jezierska A, et al. (2006) ALCAM/CD166 protects breast cancer cells against apoptosis and autophagy. Med Sci Monit. 12(8): BR263-73.
  • Kahlert C, et al. (2009) Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse. Br J Cancer. 101(3): 457-64.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-CD166 / ALCAM Antibody (PE) Rabbit Monoclonal FCM 50005-R311-P
    Anti-CD166 / ALCAM Antibody (FITC) Rabbit Monoclonal FCM 50005-R311-F
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    Anti-CD166 / ALCAM Antibody Mouse Monoclonal FCM,ICC/IF,IF 10045-MM03
    Anti-CD166 / ALCAM Antibody (FITC) Mouse Monoclonal FCM 10045-MM03-F
    Anti-CD166 / ALCAM Antibody Rabbit Polyclonal ELISA 10045-RP02
    Anti-CD166 / ALCAM Antibody (APC) Mouse Monoclonal FCM 10045-MM03-A
    Anti-CD166 / ALCAM Antibody Rabbit Polyclonal ELISA 10045-RP01
    Anti-CD166 / ALCAM Antibody Rabbit Polyclonal ELISA 10045-T16
    Anti-CD166 / ALCAM Antibody (PE) Mouse Monoclonal FCM 10045-MM03-P
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