Anti-CD16 Antibody

Cat: 90013-RP02
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Anti-CD16 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD16 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Rhesus
Specificity
Rhesus CD16
Immunogen
Recombinant Rhesus CD16 / FCGR3 protein (Catalog#90013-C08H)
Preparation
Produced in rabbits immunized with purified, recombinant Rhesus CD16 / FCGR3 (Catalog#90013-C08H; NP_001258584.1; Met1-Gly206). CD16 / FCGR3 specific IgG was purified by Rhesus CD16 / FCGR3 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD16 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:2500-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD16 Antibody (Rabbit Polyclonal antibody) Images
Cynomolgus CD16/Fc gamma  RIII Immunohistochemistry(IHC) 4787
Immunochemical staining of Rhesus macaque FCGR3 in Rhesus macaque spleen with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections).
Cynomolgus CD16/Fc gamma  RIII Immunohistochemistry(IHC) 4788
Immunochemical staining of Rhesus macaque FCGR3 in Rhesus macaque lung with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections).
CD16 Background Information

Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR). FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). CD16 protein is a multifunctional, low/intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. Mouse CD16 is encoded by a single gene, while, human CD16 is expressed as two distinct forms (CD16a/FcγRIIIa and CD16b/FcγRIIIb) encoded by two different highly homologous genes in a cell type-specific manner. CD16 is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), and clearance of immune complexes.

Full Name
Fc receptor, IgG, low affinity III
References
  • Edberg JC, et al. (2002) Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus. Arthritis Rheum. 46(8): 2132-40.
  • Li P, et al. (2002) Recombinant CD16A-Ig forms a homodimer and cross-blocks the ligand binding functions of neutrophil and monocyte Fcgamma receptors. Mol Immunol. 38(7): 527-38.
  • Li P, et al. (2007) Affinity and kinetic analysis of Fcgamma receptor IIIa (CD16a) binding to IgG ligands. J Biol Chem. 282(9): 6210-21.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD16 Antibody Mouse Monoclonal ELISA(Cap) 90013-MM05
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    Anti-CD16 Antibody Mouse Monoclonal FCM 10389-MM23
    Anti-CD16 Antibody Mouse Monoclonal FCM 11046-MM10
    Anti-CD16 Antibody (PerCP) Mouse Monoclonal FCM 11046-MM10-C
    Anti-CD16 Antibody (PE) Mouse Monoclonal FCM 10389-MM22-P
    Anti-CD16 Antibody (FITC) Mouse Monoclonal FCM 10389-MM23-F
    Anti-CD16 Antibody Rabbit Monoclonal FCM 10389-R221
    Anti-CD16 Antibody (FITC) Rabbit Monoclonal FCM 10389-R221-F
    Anti-CD16 Antibody (PerCP) Mouse Monoclonal FCM 10389-MM23-C
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