Anti-CD155 / PVR Antibody

Cat: 10109-MM11
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All CD155 / PVR Reagents
Anti-CD155 / PVR Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-CD155 / PVR Antibody
Validated applications
WB,ELISA
Species reactivity
Reacts with: Human
Specificity
Human CD155 / PVR
No cross-reactivity in ELISA with Human cell lysate (293 cell line)
Immunogen
Recombinant Human CD155 protein (Catalog#10109-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD155 extracellular domain (rh CD155; Catalog#10109-H08H; Met 1-Asn 343; NP_006496.2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #4C2B7C10
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD155 / PVR Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD155 / PVR Antibody (Mouse Monoclonal antibody) Images
Human CD155/PVR Western blot (WB) 13121

Anti-CD155 mouse monoclonal antibody at 1:500 dilution

Lane A: 293T Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:45 kDa

Observed band size:92 kDa

Anti-CD155 / PVR Antibody Alternative Names
Anti-CD155 Antibody;Anti-HVED Antibody;Anti-Necl-5 Antibody;Anti-NECL5 Antibody;Anti-PVS Antibody;Anti-TAGE4 Antibody
CD155 / PVR Background Information

CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

Immune Checkpoint
Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
poliovirus receptor
References
  • Freistadt MS, et al. (2000) Hematopoietic cells from CD155-transgenic mice express CD155 and support poliovirus replication ex vivo. Microb Pathog. 29(4): 203-12.
  • Sato T, et al. (2004) Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Genes Cells. 9(9): 791-9.
  • Kakunaga S, et al. (2004) Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling. J Biol Chem. 279(35): 36419-25.
  • Sato T, et al. (2005) Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion. Cancer Sci. 96(9): 578-89.
  • Minami Y, et al. (2007) Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells. Biochem Biophys Res Commun. 352(4): 856-60.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD155 / PVR Antibody Mouse Monoclonal WB,ELISA 90005-MM06
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 90005-RP02
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 90005-RP01
    Anti-CD155 / PVR Antibody Rabbit Monoclonal ELISA 80007-R026
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 80007-RP02
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 80007-RP01
    Anti-CD155 / PVR Antibody Mouse Monoclonal ELISA 80007-MM06
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 80007-T16
    Anti-CD155 / PVR Antibody Rabbit Monoclonal FCM,ICC/IF,IF 50259-R305
    Anti-CD155 / PVR Antibody (PE) Rabbit Monoclonal FCM 50259-R305-P
    Anti-CD155 / PVR Antibody (PerCP) Rabbit Monoclonal FCM 50259-R305-C
    Anti-CD155 / PVR Antibody (APC) Rabbit Monoclonal FCM 50259-R305-A
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 50259-RP01
    Anti-CD155 / PVR Antibody (FITC) Rabbit Monoclonal FCM 50259-R305-F
    Anti-CD155 / PVR Antibody Rabbit Monoclonal ELISA 50259-R001
    Anti-CD155 / PVR Antibody Rabbit Monoclonal ELISA 50259-R501
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 50259-RP02
    Anti-CD155 / PVR Antibody Rabbit Polyclonal WB,ELISA,IP 10109-RP02
    Anti-CD155 / PVR Antibody (APC) Mouse Monoclonal FCM 10109-MM09-A
    Anti-CD155 / PVR Antibody (FITC) Mouse Monoclonal FCM,ICC/IF,IF 10109-MM09-F
    Anti-CD155 / PVR Antibody Rabbit Monoclonal WB,ELISA,IP 10109-R114
    Anti-CD155 / PVR Antibody Rabbit Polyclonal WB,ELISA 10109-RP01
    Anti-CD155 / PVR Antibody Mouse Monoclonal FCM 10109-MM09
    Anti-CD155 / PVR Antibody (PE) Mouse Monoclonal FCM 10109-MM09-P
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