Anti-CD155 / PVR Antibody

Cat: 10109-RP02
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All CD155 / PVR Reagents
Anti-CD155 / PVR Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD155 / PVR Antibody
Validated applications
WB,ELISA,IP
Species reactivity
Reacts with: Human
Specificity
Human CD155 / PVR
Immunogen
Recombinant Human CD155 protein (Catalog#10109-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CD155 isoform a (rh CD155; Catalog#10109-H08H; NP_006496.2; Met 1-Asn 343). CD155 specific IgG was purified by human CD155 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD155 / PVR Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:1000-1:2000  
IP 0.5-1 μL/mg of lysate  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD155 / PVR Antibody (Rabbit Polyclonal antibody) Images
Human CD155/PVR Western blot (WB) 13124

Anti-CD155 rabbit polyclonal antibody at 1:500 dilution

Lane A: Jurkat Whole Cell Lysate

Lane B: HepG2 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:45 kDa

Observed band size:85 kDa

Human CD155/PVR Immunoprecipitation(IP) 17663

CD155 was immunoprecipitated using:

Lane A:0.5 mg Hela Whole Cell Lysate

Lane B:0.5 mg HepG2 Whole Cell Lysate

Lane C:0.5 mg A549 Whole Cell Lysate

2 µL anti-CD155 rabbit polyclonal antibody and 15 μl of 50 % Protein G agarose.

Primary antibody:

Anti-CD155 rabbit polyclonal antibody,at 1:330 dilution

Secondary antibody:

Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution

Developed using the odssey technique.

Performed under reducing conditions.

Predicted band size: 88 kDa

Observed band size: 88 kDa

Anti-CD155 / PVR Antibody Alternative Names
Anti-CD155 Antibody;Anti-HVED Antibody;Anti-Necl-5 Antibody;Anti-NECL5 Antibody;Anti-PVS Antibody;Anti-TAGE4 Antibody
CD155 / PVR Background Information

CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

Immune Checkpoint
Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
poliovirus receptor
References
  • Freistadt MS, et al. (2000) Hematopoietic cells from CD155-transgenic mice express CD155 and support poliovirus replication ex vivo. Microb Pathog. 29(4): 203-12.
  • Sato T, et al. (2004) Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Genes Cells. 9(9): 791-9.
  • Kakunaga S, et al. (2004) Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling. J Biol Chem. 279(35): 36419-25.
  • Sato T, et al. (2005) Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion. Cancer Sci. 96(9): 578-89.
  • Minami Y, et al. (2007) Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells. Biochem Biophys Res Commun. 352(4): 856-60.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD155 / PVR Antibody Mouse Monoclonal WB,ELISA 90005-MM06
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 90005-RP02
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 90005-RP01
    Anti-CD155 / PVR Antibody Rabbit Monoclonal ELISA 80007-R026
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 80007-RP01
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 80007-T16
    Anti-CD155 / PVR Antibody Mouse Monoclonal ELISA 80007-MM06
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 80007-RP02
    Anti-CD155 / PVR Antibody (APC) Rabbit Monoclonal FCM 50259-R305-A
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 50259-RP02
    Anti-CD155 / PVR Antibody (FITC) Rabbit Monoclonal FCM 50259-R305-F
    Anti-CD155 / PVR Antibody (PE) Rabbit Monoclonal FCM 50259-R305-P
    Anti-CD155 / PVR Antibody Rabbit Monoclonal ELISA 50259-R001
    Anti-CD155 / PVR Antibody (PerCP) Rabbit Monoclonal FCM 50259-R305-C
    Anti-CD155 / PVR Antibody Rabbit Monoclonal FCM,ICC/IF,IF 50259-R305
    Anti-CD155 / PVR Antibody Rabbit Monoclonal ELISA 50259-R501
    Anti-CD155 / PVR Antibody Rabbit Polyclonal ELISA 50259-RP01
    Anti-CD155 / PVR Antibody Mouse Monoclonal WB,ELISA 10109-MM11
    Anti-CD155 / PVR Antibody (APC) Mouse Monoclonal FCM 10109-MM09-A
    Anti-CD155 / PVR Antibody (FITC) Mouse Monoclonal FCM,ICC/IF,IF 10109-MM09-F
    Anti-CD155 / PVR Antibody Rabbit Polyclonal WB,ELISA 10109-RP01
    Anti-CD155 / PVR Antibody Rabbit Monoclonal WB,ELISA,IP 10109-R114
    Anti-CD155 / PVR Antibody Mouse Monoclonal FCM 10109-MM09
    Anti-CD155 / PVR Antibody (PE) Mouse Monoclonal FCM 10109-MM09-P
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