SLAM / CD150 (Protein | Antibody | cDNA Clone | ELISA Kit)

All SLAM / CD150 reagents are produced in house and quality controlled, including 8 SLAM / CD150 Antibody, 2 SLAM / CD150 ELISA, 26 SLAM / CD150 Gene, 3 SLAM / CD150 Lysate, 3 SLAM / CD150 Protein, 2 SLAM / CD150 qPCR. All SLAM / CD150 reagents are ready to use.

SLAM / CD150 Protein (3)

SLAM / CD150 Antibody (8)

SLAM / CD150 ELISA Kit & Match Antibody ELISA Pair Set (2)

SLAM / CD150 cDNA Clone (26)

NM_003037.2
NM_001109078.1

SLAM / CD150 Lysate (3)

SLAM / CD150 Background

CD15/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD15 receptor is expressed on thymocytes, activated and memory T cells, B cells, platelets, natural killer T cells, and mature dendritic cells, and is also detected on tumor cells of Hodgkin's lymphoma (HL) and diffuse large B-cell lymphoma with an activated B cell phenotype. Additionally, it is the immune cell receptor for measles virus (MV). As a self-ligand, CD15 performs diverse immunologic functions including T/B-cell costimulation, induction of IFN-&gamma in Th1 T-cell clones, redirection of Th2 clones to a Th1 or Th phenotype, and inhibition of apoptosis in B cells. Furthermore, CD15 was shown to be the second receptor for measles virus in addition to CD46, and the distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus.

SLAM / CD150 References

  • Tatsuo H, et al. (2002) The morbillivirus receptor SLAM (CD150). Microbiol Immunol. 46(3): 135-42.
  • Sidorenko SP, et al. (2003)The dual-function CD150 receptor subfamily: the viral attraction. Nat Immunol. 4(1): 19-24.
  • Yurchenko MY, et al. (2010) CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells. Immunol Cell Biol. 88(5): 565-74.
  • Leonard VH, et al. (2010) Measles virus selectively blind to signaling lymphocytic activation molecule (SLAM ; CD150) is attenuated and induces strong adaptive immune responses in rhesus monkeys. J Virol. 84(7): 3413-20.