Anti-SLAM / CD150 Antibody

Cat: 10837-R008
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All SLAM / CD150 Reagents
Anti-SLAM / CD150 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-SLAM / CD150 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human SLAM / CD150
No cross-reactivity in ELISA with Human CD48 / BCM1 / BLAST1 Human CD84 / SLAMF5 Human 2B4 / NKR2B4 / CD244
Immunogen
Recombinant Human CD150 protein (Catalog#10837-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human SLAMF1 / CD150 (rh SLAMF1; Catalog#10837-H08H; NP_003028.1; Met 1-Pro 258).
Source
Monoclonal Rabbit IgG Clone #8
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SLAM / CD150 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:1000-1:4000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SLAM / CD150 Antibody (Rabbit Monoclonal antibody) Images
Human CD150 / SLAM / SLAMF1 Immunohistochemistry(IHC) 3596
Immunochemical staining of human SLAMF1 in human tonsil with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Human CD150 / SLAM / SLAMF1 Immunohistochemistry(IHC) 3598
Immunochemical staining of human SLAMF1 in human lymph node with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Human CD150 / SLAM / SLAMF1 Immunohistochemistry(IHC) 3600
Immunochemical staining of human SLAMF1 in human appendix with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Anti-SLAM / CD150 Antibody Alternative Names
Anti-CD150 Antibody;Anti-CDw150 Antibody;Anti-SLAM Antibody
SLAM / CD150 Background Information

CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is expressed on thymocytes, activated and memory T cells, B cells, platelets, natural killer T cells, and mature dendritic cells, and is also detected on tumor cells of Hodgkin's lymphoma (HL) and diffuse large B-cell lymphoma with an activated B cell phenotype. Additionally, it is the immune cell receptor for measles virus (MV). As a self-ligand, CD150 performs diverse immunologic functions including T/B-cell costimulation, induction of IFN-&gamma in Th1 T-cell clones, redirection of Th2 clones to a Th1 or Th0 phenotype, and inhibition of apoptosis in B cells. Furthermore, CD150 was shown to be the second receptor for measles virus in addition to CD46, and the distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus.

Full Name
signaling lymphocytic activation molecule family member 1
References
  • Tatsuo H, et al. (2002) The morbillivirus receptor SLAM (CD150). Microbiol Immunol. 46(3): 135-42.
  • Sidorenko SP, et al. (2003)The dual-function CD150 receptor subfamily: the viral attraction. Nat Immunol. 4(1): 19-24.
  • Yurchenko MY, et al. (2010) CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells. Immunol Cell Biol. 88(5): 565-74.
  • Leonard VH, et al. (2010) Measles virus selectively blind to signaling lymphocytic activation molecule (SLAM ; CD150) is attenuated and induces strong adaptive immune responses in rhesus monkeys. J Virol. 84(7): 3413-20.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SLAM / CD150 Antibody Rabbit Polyclonal ELISA 80349-RP01
    Anti-SLAM / CD150 Antibody Rabbit Polyclonal ELISA 80349-T16
    Anti-SLAM / CD150 Antibody Rabbit Polyclonal ELISA 10837-RP02
    Anti-SLAM / CD150 Antibody Rabbit Polyclonal ELISA,IHC-P 10837-RP01
    Anti-SLAM / CD150 Antibody Mouse Monoclonal ELISA(Det) 10837-MM02
    Anti-SLAM / CD150 Antibody Mouse Monoclonal ELISA 10837-MM05
    Anti-SLAM / CD150 Antibody Rabbit Monoclonal ELISA(Cap) 10837-R110
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