CD147 Protein & Antibody (EMMPRIN, Basigin)

 Cluster of Differentiation 147 (Extracellular matrix metalloproteinase inducer)

CD147 Products

CD147 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD147/EMMPRIN	Human	CD147/EMMPRIN/Fc Protein, Recombinant	10186-H02H
CD147/EMMPRIN	Human	CD147/EMMPRIN Protein, Recombinant	10186-H08H
CD147/EMMPRIN	Human	CD147/EMMPRIN Protein, Recombinant	10186-HCCH
CD147/EMMPRIN	Mouse	CD147/EMMPRIN/Fc Protein, Recombinant	50332-M03H
CD147/EMMPRIN	Mouse	CD147/EMMPRIN Protein, Recombinant	50332-M08H

CD147 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD147/EMMPRIN	WB, ELISA	Mouse Monoclonal Antibody	10186-MM05
Human CD147/EMMPRIN	ELISA, ICC/IF, IF	CD147 / EMMPRIN / Basigin Antibody	10186-MM08
Human CD147/EMMPRIN	FCM	CD147 / EMMPRIN / Basigin Antibody ( FITC )	10186-MM08-F
Human CD147/EMMPRIN	WB, ELISA, IHC	Rabbit Monoclonal Antibody	10186-R125
Human CD147/EMMPRIN	Flow Cytometry	CD147/EMMPRIN Antibody, Rabbit MAb	10186-R125F
Human CD147/EMMPRIN	WB, ELISA	Rabbit Polyclonal Antibody	10186-RP01
Human CD147/EMMPRIN	WB, ELISA	Rabbit Polyclonal Antibody	10186-RP02
Mouse CD147/EMMPRIN	WB, ELISA	CD147/EMMPRIN Antibody, Rabbit MAb	50332-R041
Mouse CD147/EMMPRIN	WB, ELISA	Rabbit Polyclonal Antibody	50332-RP01
Mouse CD147/EMMPRIN	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50332-RP02

CD147 Related Areas

Cardiovascular>>Platelet>>CD147/EMMPRIN

Cardiovascula>>Red Blood Cell>>CD147/EMMPRIN

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>CD147/EMMPRIN

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>CD147/EMMPRIN

Cancer>>Cancer Biomarkers>>CD147/EMMPRIN

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>>CD147/EMMPRIN

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD147/EMMPRIN

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Adhesion>>CD147/EMMPRIN

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Basophils / Eosinophils / Granulocyte Markers / Neutrophils>>CD147/EMMPRIN

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>CD147/EMMPRIN

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Migration/Adhesion>>CD147/EMMPRIN

 CD147 Alternative Names

CD147, EMMPRIN, basigin, BSG, M6, OK, 5F7, TCSF [Homo sapiens]

CD147, EMMPRIN, basigin, Bsg, AI115436, AI325119, HT-7 [Mus musculus]

CD147 Background

CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.

CD147 Related Studies

1. Tang Y, et al. (2004) Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN. Mol Cancer Res. 2(2): 73-80.
2. Wilson MC, et al. (2005) Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem. 280(29): 27213-21.
3. Curtin KD, et al. (2005) Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture. J Cell Sci. 118(Pt 12): 2649-60.
4. Zhu H, et al. (2009) A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity. Cancer Biol Ther. 8(11): 1035-44. Zhu H, et al. (2009) A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity. Cancer Biol Ther. 8(11): 1035-44.
5. Seizer P, et al. (2009) EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction. Thromb Haemost. 101(4): 682-6.
6. Moonsom S, et al. (2010) A Competitive ELISA for Quantifying Serum CD147: Reduction of Soluble CD147 Levels in Cancer Patient Sera. Hybridoma (Larchmt). 29(1): 45-52.