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CD147 / EMMPRIN / Basigin Antibody, Rabbit PAb, Antigen Affinity Purified

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    Mouse CD147/BSG Antibody Product Information
    Immunogen:Recombinant Mouse CD147 protein (Catalog#50332-M08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Mouse BSG / CD147 extracellular domain (rM BSG / CD147; Catalog#50332-M08H; NP_001070652.1; Met 1-Arg 209). BSG / CD147 specific IgG was purified by mouse CD147 affinity chromatography.
    Other CD147/BSG Antibody Products
    Reactivity: Human  
    Application: ELISA  WB  
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    10186-RP01-400
    10186-RP01-200
    10186-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  IHC-P  
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    • Slide 1
    • Slide 1
    10186-MM05-50
    10186-MM05-200
    10186-MM05-100
    10186-MM05-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10186-R125-A-25
    10186-R125-A-100
    25 Test 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  WB  IHC-P  FCM  IF  IP  IHC-Fr  ICC/IF  
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    • Slide 1
    • Slide 1
    • Slide 1
    • Slide 1
    • Slide 1
    • Slide 1
    • Slide 1
    • Slide 1
    • Slide 1
    • Slide 1
    10186-R125-50
    10186-R125-100
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: 
      10186-R118-50
      10186-R118-100
      10186-R118-1
      50 µg 
      100 µg 
      1 mg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      • Slide 1
      10186-R125-P-25
      10186-R125-P-100
      25 Test 
      100 Tests 
      Add to Cart
      Reactivity: Human  
      Application: FCM  IF  ICC/IF  
      • Slide 1
      • Slide 1
      10186-MM08-F-25
      10186-MM08-F-100
      25 Test 
      100 Tests 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10186-MM08-A-25
      10186-MM08-A-100
      25 Test 
      100 Tests 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  FCM  IF  ICC/IF  
      • Slide 1
      • Slide 1
      10186-MM08-50
      10186-MM08-200
      10186-MM08-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      • Slide 1
      10186-MM08-P-25
      10186-MM08-P-100
      25 Test 
      100 Tests 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  IHC-P  
      • Slide 1
      • Slide 1
      10186-RP02-50
      10186-RP02-200
      10186-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  IF  ICC/IF  
      • Slide 1
      • Slide 1
      • Slide 1
      10186-R125-F-25
      10186-R125-F-100
      25 Test 
      100 Tests 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  IF  ICC/IF  
      • Slide 1
      50332-R041-50
      50332-R041-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  
        50332-RP01-400
        50332-RP01-200
        50332-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart

        Anti-Histone H3 rabbit monoclonal antibody at 1:200 dilution

        Lane A: NIH3T3 Whole Cell Lysate

        Lane B: Hela Whole Cell Lysate

        Lysates/proteins at 30 μg per lane.

        Secondary

        Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

        Developed using the ECL technique.

        Performed under reducing conditions.

        Predicted band size:15 kDa

        Observed band size:17 kDa

        CD147/EMMPRIN/Basigin Background

        CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.

        Mouse CD147/EMMPRIN/Basigin References
      • Tang Y, et al. (2004) Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN. Mol Cancer Res. 2(2): 73-80.
      • Wilson MC, et al. (2005) Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem. 280(29): 27213-21.
      • Curtin KD, et al. (2005) Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture. J Cell Sci. 118(Pt 12): 2649-60.
      • Zhu H, et al. (2009) A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity. Cancer Biol Ther. 8(11): 1035-44. Zhu H, et al. (2009) A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity. Cancer Biol Ther. 8(11): 1035-44.
      • Seizer P, et al. (2009) EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction. Thromb Haemost. 101(4): 682-6.
      • Moonsom S, et al. (2010) A Competitive ELISA for Quantifying Serum CD147: Reduction of Soluble CD147 Levels in Cancer Patient Sera. Hybridoma (Larchmt). 29(1): 45-52.
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        Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"