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CD147 / EMMPRIN / Basigin Antibody, Mouse MAb

  • CD147 / EMMPRIN / Basigin Antibody, Mouse MAb, Immunohistochemistry
  • CD147 / EMMPRIN / Basigin Antibody, Mouse MAb, Immunohistochemistry
  • CD147 / EMMPRIN / Basigin Antibody, Mouse MAb, Immunohistochemistry
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Human CD147/BSG Antibody Product Information
Immunogen:Recombinant Human CD147 protein (Catalog#10186-H08H)
Clone ID:6H11C1
Ig Type:Mouse IgG2a
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD147. (rh CD147; Catalog#10186-H08H; NP_940991.1; Met 1-His 205). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Human CD147/BSG Antibody IHC Application Image
CD147 / EMMPRIN / Basigin Antibody, Mouse MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human CD147 in human esophagus with mouse monoclonal antibody (10 µg/mL, formalin-fixed paraffin embedded sections). The image showing membrane staining of squamous epithelium cell.
CD147 / EMMPRIN / Basigin Antibody, Mouse MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human CD147 in human gastric cancer with mouse monoclonal antibody (10 µg/mL, formalin-fixed paraffin embedded sections). The image showing membrane staining of epithelium cell.
CD147 / EMMPRIN / Basigin Antibody, Mouse MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human CD147 in human stomach with mouse monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections). The image showing membrane staining of epithelium cell.
Other CD147/BSG Antibody Products
Reactivity: Human  
Application: ELISA  WB  
  • Slide 1
10186-RP01-400
10186-RP01-200
10186-RP01-100
400 µg 
200 µg 
100 µg 
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Reactivity: Human  
Application: FCM  
  • Slide 1
10186-R125-A-25
10186-R125-A-100
25 Test 
100 Tests 
Add to Cart
Reactivity: Human  
Application: ELISA  WB  IHC-P  FCM  IF  IP  IHC-Fr  ICC/IF  
  • Slide 1
  • Slide 1
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  • Slide 1
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  • Slide 1
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  • Slide 1
10186-R125-50
10186-R125-100
50 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: 
    10186-R118-50
    10186-R118-100
    10186-R118-1
    50 µg 
    100 µg 
    1 mg 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    • Slide 1
    10186-R125-P-25
    10186-R125-P-100
    25 Test 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: FCM  IF  ICC/IF  
    • Slide 1
    • Slide 1
    10186-MM08-F-25
    10186-MM08-F-100
    25 Test 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10186-MM08-A-25
    10186-MM08-A-100
    25 Test 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  FCM  IF  ICC/IF  
    • Slide 1
    • Slide 1
    10186-MM08-50
    10186-MM08-200
    10186-MM08-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    • Slide 1
    10186-MM08-P-25
    10186-MM08-P-100
    25 Test 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  IHC-P  
    • Slide 1
    • Slide 1
    10186-RP02-50
    10186-RP02-200
    10186-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: FCM  IF  ICC/IF  
    • Slide 1
    • Slide 1
    • Slide 1
    10186-R125-F-25
    10186-R125-F-100
    25 Test 
    100 Tests 
    Add to Cart
    Reactivity: Mouse  
    Application: ELISA  
      50332-RP02-50
      50332-RP02-200
      50332-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  IF  ICC/IF  
      • Slide 1
      50332-R041-50
      50332-R041-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  
        50332-RP01-400
        50332-RP01-200
        50332-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        CD147/EMMPRIN/Basigin Background

        CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.

        Human CD147/EMMPRIN/Basigin References
      • Tang Y, et al. (2004) Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN. Mol Cancer Res. 2(2): 73-80.
      • Wilson MC, et al. (2005) Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem. 280(29): 27213-21.
      • Curtin KD, et al. (2005) Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture. J Cell Sci. 118(Pt 12): 2649-60.
      • Zhu H, et al. (2009) A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity. Cancer Biol Ther. 8(11): 1035-44. Zhu H, et al. (2009) A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity. Cancer Biol Ther. 8(11): 1035-44.
      • Seizer P, et al. (2009) EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction. Thromb Haemost. 101(4): 682-6.
      • Moonsom S, et al. (2010) A Competitive ELISA for Quantifying Serum CD147: Reduction of Soluble CD147 Levels in Cancer Patient Sera. Hybridoma (Larchmt). 29(1): 45-52.
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        Catalog: 10186-MM05-50
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        Datasheet & Documentation

        All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
        Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"