Anti-CD147 Antibody

Cat: 10186-RP01
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All CD147 Reagents
CRO Services
Product recommended

All CD147 Reagents
Anti-CD147 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD147 Antibody
Validated applications
WB,ELISA
Species reactivity
Reacts with: Human
Specificity
Human CD147
Immunogen
Recombinant Human CD147 protein (Catalog#10186-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CD147. (rh CD147; Catalog#10186-H08H; NP_940991.1; Met 1-His 205). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD147 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD147 Antibody (Rabbit Polyclonal antibody) Images
Human CD155/PVR Western blot (WB) 13123

Anti-CD155 rabbit polyclonal antibody at 1:500 dilution

Lane A: HepG2 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:72-95 kDa

Observed band size:85 kDa

(We are unsure as to the identity of these extra bands.)

Human CD147/EMMPRIN/Basigin Western blot (WB) 13137
Anti-CD147 Antibody Alternative Names
Anti-5F7 Antibody;Anti-Basigin Antibody;Anti-CD147 Antibody;Anti-EMMPRIN Antibody;Anti-M6 Antibody;Anti-OK Antibody;Anti-TCSF Antibody
CD147 Background Information

CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.

Full Name
basigin (Ok blood group)
References
  • Tang Y, et al. (2004) Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN. Mol Cancer Res. 2(2): 73-80.
  • Wilson MC, et al. (2005) Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem. 280(29): 27213-21.
  • Curtin KD, et al. (2005) Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture. J Cell Sci. 118(Pt 12): 2649-60.
  • Zhu H, et al. (2009) A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity. Cancer Biol Ther. 8(11): 1035-44. Zhu H, et al. (2009) A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity. Cancer Biol Ther. 8(11): 1035-44.
  • Seizer P, et al. (2009) EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction. Thromb Haemost. 101(4): 682-6.
  • Moonsom S, et al. (2010) A Competitive ELISA for Quantifying Serum CD147: Reduction of Soluble CD147 Levels in Cancer Patient Sera. Hybridoma (Larchmt). 29(1): 45-52.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD147 Antibody Rabbit Monoclonal ELISA,ICC/IF,IF 50332-R041
    Anti-CD147 Antibody Rabbit Polyclonal ELISA 50332-RP01
    Anti-CD147 Antibody Rabbit Polyclonal ELISA 50332-RP02
    Anti-CD147 Antibody (PE) Mouse Monoclonal FCM 10186-MM08-P
    Anti-CD147 Antibody Rabbit Monoclonal ELISA(Det) 10186-R118
    Anti-CD147 Antibody (FITC) Rabbit Monoclonal FCM,ICC/IF,IF 10186-R125-F
    Anti-CD147 Antibody (PE) Rabbit Monoclonal FCM 10186-R125-P
    Anti-CD147 Antibody Rabbit Polyclonal ELISA,IHC-P 10186-RP02
    Anti-CD147 Antibody Mouse Monoclonal ELISA,ELISA(Cap),IHC-P 10186-MM05
    Anti-CD147 Antibody (APC) Mouse Monoclonal FCM 10186-MM08-A
    Anti-CD147 Antibody Rabbit Monoclonal WB,ELISA,IHC-P,IHC-Fr,FCM,ICC/IF,IF,IP 10186-R125
    Anti-CD147 Antibody Mouse Monoclonal ELISA,FCM,ICC/IF,IF 10186-MM08
    Anti-CD147 Antibody (FITC) Mouse Monoclonal FCM,ICC/IF,IF 10186-MM08-F
    Anti-CD147 Antibody (APC) Rabbit Monoclonal FCM 10186-R125-A
    info info
    添加购物车成功! 添加购物车失败!