CD146 Protein & Antibody (MCAM)

Cluster of Differentiation 146 (Melanoma Cell Adhesion Molecule)

CD146 Protein & Antibody Products

CD146 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD146/MCAM	Human	CD146/MCAM/Fc Protein, Recombinant	10115-H02H
CD146/MCAM	Human	CD146/MCAM Protein, Recombinant	10115-H08H
CD146/MCAM	Mouse	CD146 / MCAM Protein, Recombinant	50794-M08H

  10115-H02H: When 3 x 10⁴ cells/well are added to human CD146 coated plates (0.8 µg/mL, 100 µL/well) , approximately > 30 % will adhere after one hour at 37 ℃. Measured by the ability of the immobilized protein to support the adhesion of the HUVEC human umbilical vein endothelial cell line.

  10115-H08H: When 3 x 10⁴ cells/well are added to human CD146 coated plates (0.8 µg/mL, 100 µL/well) , approximately > 50 % will adhere after one hour at 37 ℃. Measured by the ability of the immobilized protein to support the adhesion of the HUVEC human umbilical vein endothelial cell line.

CD146 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD146/MCAM	FCM	CD146 / MCAM Antibody ( PE )	10115-MM01-P
Human CD146/MCAM	WB, ELISA	Mouse Monoclonal Antibody	10115-MM04
Human CD146/MCAM	WB, ELISA	Mouse Monoclonal Antibody	10115-MM05
Human CD146/MCAM	WB, IHC	Rabbit Monoclonal Antibody	10115-R005
Human CD146/MCAM	IHC	CD146/MCAM Antibody, Rabbit MAb	10115-R012
Human CD146/MCAM	ELISA, IHC	Rabbit Monoclonal Antibody	10115-R044
Human CD146/MCAM	WB, FCM	CD146 / MCAM Antibody ( FITC )	10115-R044-F
Human CD146/MCAM	ELISA	Rabbit Polyclonal Antibody	10115-RP01
Human CD146/MCAM	WB, ELISA, IHC	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10115-RP02

CD146 ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD146/MCAM	ELISA	CD146/MCAM ELISA Kit	SEK10115

CD146 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD146/MCAM	Human	Homo sapiens CD146/MCAM cDNA Clone(NM_006500.2)	HG10115-M
CD146/MCAM	Mouse	Mouse CD146/MCAM cDNA Clone / ORF Clone	MG50794-G

CD146 Alternative Names

CD146, MCAM, Gicerin, MUC18 [Homo sapiens]

CD146, Mcam, gicerin, CD149, 1-gicerin, AV025631, Muc18, s-endo, s-gicerin [Mus musculus]

CD146 Related Areas

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>CD146/MCAM

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>CD146/MCAM

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>CD146/MCAM

Cancer>>Cancer Biomarkers>>CD146/MCAM

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>CD146/MCAM

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Adhesion>>CD146/MCAM

CD146 Background

The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body, and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumours, and thus has been suggested to play an important role in tumour progression and the development of metastasis in certain human carcinomas.

CD146 Related Studies

1. Mills L, et al. (2002) Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res. 62(17): 5106-14.
2. Taira E, et al. (2004) Characterization of Gicerin/MUC18/CD146 in the rat nervous system. J Cell Physiol. 198(3): 377-87.
3. Fritzsche FR, et al. (2008) CD146 protein in prostate cancer: revisited with two different antibodies. Pathology. 40(5): 457-64.
4. Bidlingmaier S, et al. (2009) Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 69(4): 1570-7.
5. Boneberg EM, et al. (2009) Soluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process. Microvasc Res. 78(3): 325-31.