All CD146 / MCAM reagents are produced in house and quality controlled, including 17 CD146 / MCAM Antibody, 2 CD146 / MCAM ELISA, 26 CD146 / MCAM Gene, 3 CD146 / MCAM IPKit, 3 CD146 / MCAM Lysate, 3 CD146 / MCAM Protein, 2 CD146 / MCAM qPCR. All CD146 / MCAM reagents are ready to use.
Recombinant CD146 / MCAM proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc.
CD146 / MCAMantibodies are validated with different applications, which are FCM, ICC/IF, IF, ELISA, IHC-P, WB, IP, ELISA(Det), ELISA(Cap).
CD146 / MCAMcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD146 / MCAM of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CD146 / MCAMELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body, and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumours, and thus has been suggested to play an important role in tumour progression and the development of metastasis in certain human carcinomas.