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CD14  Protein

All CD14 Reagents

Expression host: Human Cells  
10073-H01H-50
10073-H01H-100
50 µg 
100 µg 
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Expression host: Human Cells  
10073-H08H-50
10073-H08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50023-M08H-200
50023-M08H-100
200 µg 
100 µg 
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Expression host: Human Cells  
50023-M03H-200
50023-M03H-100
200 µg 
100 µg 
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Expression host: Human Cells  
80308-R02H-200
80308-R02H-100
200 µg 
100 µg 
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Expression host: Human Cells  
80308-R08H-200
80308-R08H-100
200 µg 
100 µg 
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Expression host: Human Cells  
90174-C08H-50
90174-C08H-100
50 µg 
100 µg 
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CD14 Related Area

CD14 Summary & Protein Information

CD14 Background

Gene Summary: The CD14 protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. This CD14 protein cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein.
General information above from NCBI
Subunit structure: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Tissue specificity: Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
Post-translational: N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169}.
Sequence similarity: Contains 11 LRR (leucine-rich) repeats. {ECO:0000305}.
General information above from UniProt

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 14 (CD14) is a member of the CD system. It takes its name from its inclusion in the CD molecule surface marker proteins. CD14 exists in two forms: a form anchored into the membrane or a soluble form. CD14 was found expressed in macrophages, neutrophil granulocyte and dendritic cells. The major function is serve as a co-receptor (along with TLR4 and MD-2) for the bacterial lipopolysaccharide (LPS) and other pathogen-associated molecular patterns.

CD14 Alternative Name

CD14,CD14 antigen,monocyte differentiation antigen CD14, [human]

CD14 Related Studies

  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • SD Wright, et al. (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science. 249 (4975): 1431-3.
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