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Product Catalog
> CD137 Protein (4-1BB, TNFRSF9 Protein) CD137 Protein (4-1BB, TNFRSF9 Protein)
Cluster of Differentiation 137 (Tumor Necrosis Factor Receptor Superfamily, member 9)
CD137 Products
CD137 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| CD137/4-1BB/TNFRSF9 | Human | CD137/4-1BB/TNFRSF9/Fc Protein, Recombinant |
10041-H03H |
| CD137/4-1BB/TNFRSF9 | Human | CD137/4-1BB/TNFRSF9 Protein, Recombinant | 10041-H08H |
| CD137/4-1BB/TNFRSF9 | Mouse | CD137/4-1BB/TNFRSF9 Protein, Recombinant | 50811-M02H |
CD137 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human CD137/4-1BB/TNFRSF9 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 10041-RP02 |
CD137 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| CD137/4-1BB/TNFRSF9 | Human | Homo sapiens CD137/4-1BB/TNFRSF9 cDNA Clone(NM_001561.4) | HG10041-M |
| CD137/4-1BB/TNFRSF9 | Human | Human CD137 / 4-1BB / TNFRSF9 ORF Expression Clone, HA-tagged | HG10041-M-Y |
| CD137/4-1BB/TNFRSF9 | Mouse | Mouse CD137/4-1BB/TNFRSF9 cDNA Clone / ORF Clone | MG50811-G |
| CD137/4-1BB/TNFRSF9 | Canine | Canine TNFRSF9 Gene cDNA Clone / ORF Clone | DG70095-G |
| CD137/4-1BB/TNFRSF9 | Rat | Rat CD137/4-1BB/TNFRSF9 cDNA Clone / ORF Clone | RG80176-G |
CD137 Related Areas
Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD137/4-1BB/TNFRSF9
Immunology>>Cytokine & Receptor>>TNF Superfamily>>CD137/4-1BB/TNFRSF9
Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Co-stimulatory Molecules>>CD137/4-1BB/TNFRSF9
Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>CD137/4-1BB/TNFRSF9
Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>CD137/4-1BB/TNFRSF9
Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>CD137/4-1BB/TNFRSF9
CD137 Alternative Names
CD137, 4-1BB, TNFRSF9, CDw137, ILA, MGC2172 [Homo sapiens]
Cd137, 4-1BB, Tnfrsf9, CDw137, ILA, RP23-272N19.6, A930040I11Rik, AA408498, AI325004, Ly63 [Mus musculus]
CD137 Background
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials.
CD137 Related Studies
- Sica G, et al. (1999) Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy. Arch Immunol Ther Exp (Warsz). 47(5): 275-9.
- Nam KO, et al. (2005) The therapeutic potential of 4-1BB (CD137) in cancer. Curr Cancer Drug Targets. 5(5): 357-63.
- Wang Q, et al. (2008) Analysis of CD137 and CD137L expression in human primary tumor tissues. Croat Med J. 49(2): 192-200.
- Melero I, et al. (2008) Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci. 29(8): 383-90.
- Thum E, et al. (2009) CD137, implications in immunity and potential for therapy. Front Biosci. 14: 4173-88.
CD137/4-1BB related areas, pathways, and other information
TNF Superfamily Ligands
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TNF Receptor Superfamily
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