CD136 / MST1R Protein & Antibody

Cluster of Differentiation 136 / Macrophage Stimulating 1 Receptor (c-met-related tyrosine kinase)

CD136 / MST1R Products

CD136 / MST1R Protein, Recombinant

Molecule	Species	Description	Cat. No
CD136/MST1R	Human	CD136/MST1R Protein, Recombinant	11608-H08H

  11608-H08H:  Measured by its ability to bind human PKBa in a functional Elisa.

CD136 / MST1R Antibody

Molecule	Application	Description	Cat. No
Human CD136/MST1R	WB, ELISA	CD136 / MST1R Antibody (Antigen Affinity Purified)	11608-RP02

CD136 / MST1R cDNA Clone

Molecule	Species	Description	Cat. No
CD136/MST1R	Human	Homo sapiens CD136/MST1R cDNA Clone	HG11608-M

CD136 / MST1R Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>CD136/MST1R

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>CD136/MST1R

Immunology>>Cluster of Differentiation>>CD136/MST1R

CD136 / MST1R Alternative Names

CD136, MST1R, CDw136, PTK8, RON [Homo sapiens]

Cd136, Mst1r, CDw136, Fv-2, Fv2, PTK8, Ron, STK [Mus musculus]

CD136 / MST1R Background

The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As tyrosine kinase receptor comprised of an extra-cellular domain, MST1R protein contains the ligand binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in vivo during injury. This assessment of gene expression indicates the importance of genetic factors in contributing to lung injury, and points to strategies for intervention in the progression of inflammatory diseases. It had been shown that MST1R/CD136 plays a critical role in Ni-induced lung injury in mice. The overexpression of MSP, MT-SP1, and MST1R was a strong independent indicator of both metastasis and death in human breast cancer patients and significantly increased the accuracy of an existing gene expression signature for poor prognosis. Stimulation of MST1R leads to its transphosphorylation and the ultimate activation of numerous intracellular signaling pathways, such as the classical mitogen-activated protein kinase pathway, the phosphotidylinositol (PI)3-kinase pathway, and the JNK pathway.

CD136 / MST1R Related Studies

1. Ronsin C, et al. (1993) A novel putative receptor protein tyrosine kinase of the met family. Oncogene. 8: 1195-1202.
2. McDowell SA, et al. (2002) The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury. Am J Respir Cell Mol Biol. 26(1): 99-104.
3. Angeloni D, et al. (2003) C to A single nucleotide polymorphism in intron 18 of the human MST1R (RON) gene that maps at 3p21.3. Mol Cell Probes. 17(2-3): 55-7.
4. Mallakin A, et al. (2006) Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury. Am J Respir Cell Mol Biol. 34(1): 15-27.
5. Welm AL, et al. (2007) The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans. Proc Natl Acad Sci U S A. 104(18): 7570-5.