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CD136 / MST1R Antibody Datasheet
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CD136 / MST1R Antibody Product Information
Recombinant Human CD136 / MST1R protein (Catalog#11608-H08H)
|Antibody Type :||Mouse Monoclonal Antibody ( Mouse mAb Service Platform )|
Clone ID :
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS with 5% trehalose|
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD136 / MST1R (rh CD136 / MST1R; Catalog#11608-H08H; Q04912; Met 1-Leu 571). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
CD136 / MST1R Antibody Usage Guide
Human CD136 / MST1R
|Has little cross-reactivity in ELISA with
Human cell lysate (293 cell line)
|Direct ELISA :||This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human CD136.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
CD136 / MST1R Antibody Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|CD136/MST1R||Human||CD136/MST1R Protein, Recombinant||11608-H08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human CD136/MST1R||WB, ELISA||CD136 / MST1R Antibody||11608-MM02|
|Human CD136/MST1R||WB, ELISA||CD136 / MST1R Antibody||11608-MM04|
|Human CD136/MST1R||WB, ELISA||CD136 / MST1R Antibody (Antigen Affinity Purified)||11608-RP02|
CD136 / MST1R Antibody Background
Macrophage stimulating 1 receptor (MST1R), also known as RON, CD136, is tyrosine kinase receptor comprised of an extra-cellular domain that contains the ligand binding pocket and an intracellular region where the kinase domain is located. It controls cell survival and motility programs related to invasive growth. MST1R/CD136 is a transmembrane receptor for macrophage stimulating protein. The c-met-related tyrosine kinase MST1R, has been shown to play a critical role in Ni-induced lung injury in mice. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in vivo during injury. This assessment of gene expression indicates the importance of genetic factors in contributing to lung injury, and points to strategies for intervention in the progression of inflammatory diseases. Stimulation of Mst1r leads to its transphosphorylation and the ultimate activation of numerous intracellular signaling pathways, such as the classical mitogen-activated protein kinase pathway, the phosphotidylinositol (PI)3-kinase pathway, and the JNK pathway. Additionally, the overexpression of MSP, MT-SP1, and MST1R was a strong independent indicator of both metastasis and death in human breast cancer patients and significantly increased the accuracy of an existing gene expression signature for poor prognosis.
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