All CD133 reagents are produced in house and quality controlled, including 1 CD133 Antibody, 25 CD133 Gene, 2 CD133 Lysate, 2 CD133 Protein, 2 CD133 qPCR. All CD133 reagents are ready to use.
Recombinant CD133 proteins are expressed by HEK293 Cells with fusion tags as N-mouse IgG1-Fc, N-His.
CD133antibodies are validated with different applications, which are WB.
CD133cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD133 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CD133, also known as PROM1 and Prominin 1, is a pentaspan transmembrane glycoprotein which belongs to the prominin family. It localizes to membrane protrusions and is often expressed on adult stem cells. CD133 is known to play a role in maintaining stem cell properties by suppressing differentiation. CD133 binds cholesterol in cholesterol-containing plasma membrane microdomains. It is proposed to play a role in apical plasma membrane organization of epithelial cells. CD133 is also involved in regulation of MAPK and Akt signaling pathways. Mutations in PROM1 gene have been shown to result in retinitis pigmentosa and Stargardt disease. PROM1 gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Expression of this gene is also associated with several types of cancer.