CD132 Protein & Antibody (IL2RG, IL-2RG Protein)

Cluster of Differentiation 132 (Interleukin 2 Receptor gamma )

CD132 / IL2RG Products

CD132 / IL2RG Protein, Recombinant

Molecule	Species	Description	Cat. No
CD132/IL2RG	Mouse	CD132/IL2RG/Fc Protein, Recombinant	50087-M03H
CD132/IL2RG	Mouse	CD132/IL2RG Protein, Recombinant	50087-M08H
CD132/IL2RG	Human	IL2RG / CD132 Protein, Recombinant	10555-H08B

CD132 / IL2RG Antibody

Molecule	Application	Description	Cat. No
Mouse CD132/IL2RG	WB, ELISA	CD132 / IL2RG Antibody	50087-RP01
Mouse CD132/IL2RG	WB, ELISA	CD132 / IL2RG Antibody (Antigen Affinity Purified)	50087-RP02

CD132 / IL2RG cDNA Clone

Molecule	Species	Description	Cat. No
CD132/IL2RG	Human	CD132/IL2RG cDNA Clone(NM_000206.1)	HG10555-M
CD132/IL2RG	Mouse	CD132/IL2RG cDNA Clone	MG50087-M
CD132/IL2RG	Rat	IL2RG cDNA Clone / ORF Clone	RG80197-G
CD132/IL2RG	Cynomolgus	Cynomolgus monkey IL2RG cDNA Clone / ORF Clone	KG90119-G

CD132 / IL2RG Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>CD132/IL2RG

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>CD132/IL2RG

CD132 / IL2RG Alternative Names

CD132, IL2RG, IMD4, SCIDX, SCIDX1 [Homo sapiens]

CD132, Il2rg, RP23-440J15.2, [g]c, gamma(c), gc [Mus musculus]

Cd132, Il2rg, Ab2-183 [Rattus norvegicus]

CD132 / IL2RG Background

The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (XSCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity, and the requirement for IL-2R gamma in IL-4-mediated phosphorylation of insulin receptor substrate-1. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

CD132 / IL2RG Related Studies

1. Russell SM, et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. 262 (5141): 1880-3.
2. Miyazaki T, et al. (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science. 266 (5187): 1045-7.
3. Takeshita T, et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science. 257 (5068): 379-82.