Anti-CD132 Antibody

Cat: 50087-RP01
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All CD132 Reagents
Anti-CD132 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD132 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse CD132
Immunogen
Recombinant Mouse CD132 / IL2RG protein (Catalog#50087-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse CD132 / IL2RG (rM CD132 / IL2RG; Catalog#50087-M08H; NP_038591.1; Met 1-Ala 263). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD132 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD132 Antibody Alternative Names
Anti-CD132 Antibody;Anti-gamma(c) Antibody;Anti-gc Antibody;Anti-[g]c Antibody
CD132 Background Information

The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (XSCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

Full Name
interleukin 2 receptor, gamma
References
  • Russell SM, et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. 262 (5141): 1880-3.
  • Miyazaki T, et al. (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science. 266 (5187): 1045-7.
  • Takeshita T, et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science. 257 (5068): 379-82.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD132 Antibody Rabbit Polyclonal ELISA 80197-RP01
    Anti-CD132 Antibody Rabbit Polyclonal ELISA 80197-T16
    Anti-CD132 Antibody Rabbit Polyclonal WB,ELISA 50087-RP02
    Anti-CD132 Antibody Rabbit Monoclonal ELISA 50087-R004
    Anti-CD132 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 50087-R005
    Anti-CD132 Antibody Rabbit Monoclonal ELISA(Cap),FCM,ICC/IF,IF 50087-R011
    Anti-CD132 Antibody (PE) Rabbit Monoclonal FCM 50087-R011-P
    Anti-CD132 Antibody Mouse Monoclonal ELISA 10555-MM10
    Anti-CD132 Antibody Rabbit Monoclonal ELISA 10555-R044
    Anti-CD132 Antibody Rabbit Polyclonal ELISA 10555-RP01
    Anti-CD132 Antibody Rabbit Polyclonal WB,IP 101868-T36
    Anti-CD132 Antibody Rabbit Polyclonal ELISA 10555-T16
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