CD131 / CSF2RB Protein & Antibody (IL3RB, IL5RB)

Cluster of Differentiation 131 / Colony Stimulating Factor 2 Receptor, Beta, low-affinity (granulocyte-macrophage)

CD131 / CSF2RB Products

CD131 / CSF2RB Protein, Recombinant

Molecule	Species	Description	Cat. No
CD131/CSF2RB/IL3RB/IL5RB	Human	CD131/CSF2RB Protein, Recombinant	10516-H08H

  10516-H08H:

1. Immobilized human CD131 at 10 µg/mL (100 µl/well) can bind biotinylated human EPOR/Fc with a linear range of 0.16-4 µg/ml. Measured by its binding ability in a functional ELISA.

2. Immobilized human CD131 at 10 µg/mL (100 µl/well) can bind human GMCSF with a linear range of 0.032-4 µg/ml. Measured by its binding ability in a functional ELISA.

CD131 / CSF2RB Antibody

Molecule	Application	Description	Cat. No
Human CD131/CSF2RB/IL3RB/IL5RB	WB, ELISA	CD131/CSF2RB/IL3RB/IL5RB Antibody, Rabbit PAb	10516-RP01
Human CD131/CSF2RB/IL3RB/IL5RB	WB, ELISA	CD131/CSF2RB/IL3RB/IL5RB Antibody, Rabbit PAb (Antigen Affinity Purified)	10516-RP02
Human CD131/CSF2RB/IL3RB/IL5RB	WB, ELISA	CD131/CSF2RB/IL3RB/IL5RB Antibody, Mouse MAb	10516-MM11

CD131 / CSF2RB cDNA Clone

Molecule	Species	Description	Cat. No
CD131/CSF2RB/IL3RB/IL5RB	Human	Homo sapiens CD131/CSF2RB cDNA Clone(NM_000395.2)	HG10516-M
CD131/CSF2RB/IL3RB/IL5RB	Rat	CSF2RB cDNA Clone / ORF Clone	RG80323-G

CD131 / CSF2RB Alternative Names

CD131, CSF2RB, CDw131, IL3RB, IL5RB, GM-CSF/IL-3/IL-5 receptor common beta-chain [Homo sapiens]

CDw131, Csf2rb1, Il3rb, Il5rb, Il3r, Il3rb1, AI848964, AIC2B, Bc, Csfgmrb, MGC130522, GM-CSF/IL-3/IL-5 receptor common beta-chain [Mus musculus]

CD131 / CSF2RB Related Areas

Cancer>>Growth Factor & Receptor>>CSF & Receptor>>CD131/CSF2RB/IL3RB/IL5RB

Immunology>>Cytokine & Receptor>>CSF & Receptor>>CD131/CSF2RB/IL3RB/IL5RB

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>CD131/CSF2RB/IL3RB/IL5RB

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD131/CSF2RB/IL3RB/IL5RB

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Basophils / Granulocyte Markers>>CD131/CSF2RB/IL3RB/IL5RB

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>CD131/CSF2RB/IL3RB/IL5RB

CD131 / CSF2RB Background

Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

CD131 / CSF2RB Related Studies

1. Selleri S, et al. (2008) GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells. J Transl Med. 6:17.
2. Woodcock, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13(21): 5176-85.
3. Dirksen U, et al. (1997) Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression. J Clin Invest. 100(9): 2211-7.