Anti-CD131 Antibody

Cat: 10516-RP02
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All CD131 Reagents
Anti-CD131 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD131 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CD131
Immunogen
Recombinant Human CSF2RB protein (Catalog#10516-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CSF2RB (rh CSF2RB; Catalog#10516-H08H; NP_000386.1; Met 1-Trp 443). CSF2RB specific IgG was purified by human CSF2RB affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD131 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD131 Antibody Alternative Names
Anti-CD131 Antibody;Anti-CDw131 Antibody;Anti-IL3RB Antibody;Anti-IL5RB Antibody;Anti-SMDP5 Antibody
CD131 Background Information

Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

Full Name
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
References
  • Selleri S, et al. (2008) GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells. J Transl Med. 6:17.
  • Woodcock, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13(21): 5176-85.
  • Dirksen U, et al. (1997) Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression. J Clin Invest. 100(9): 2211-7.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD131 Antibody Rabbit Polyclonal IHC-P 101978-T08
    Anti-CD131 Antibody Rabbit Polyclonal ELISA 10516-RP01
    Anti-CD131 Antibody (PE) Mouse Monoclonal FCM 10516-MM01-P
    Anti-CD131 Antibody Rabbit Monoclonal ELISA 10516-R001
    Anti-CD131 Antibody Mouse Monoclonal FCM 10516-MM01
    Anti-CD131 Antibody (APC) Mouse Monoclonal FCM 10516-MM01-A
    Anti-CD131 Antibody Mouse Monoclonal ELISA 10516-MM11
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