Anti-CD131 Antibody (PE)

Cat: 10516-MM10-P
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All CD131 Reagents
Anti-CD131 Antibody (PE) (Mouse Monoclonal antibody) General Information
Product name
Anti-CD131 Antibody (PE)
Validated applications
Species reactivity
Reacts with: Human
Human CD131
Recombinant Human CD131 / CSF2RB / IL3RB / IL5RB protein (Catalog#10516-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD131 / CSF2RB / IL3RB / IL5RB (rh CD131 / CSF2RB / IL3RB / IL5RB; Catalog#10516-H08H; NP_000386.1; Met1-Trp443) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Monoclonal Mouse IgG1 Clone #10
Protein A
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
10 μl/Test, 0.1 mg/ml
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-CD131 Antibody (PE) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD131 Antibody (PE) (Mouse Monoclonal antibody) Images
Human CD131/CSF2RB/IL3RB/IL5RB Flow Cytometry (FC) 5403
Flow cytometric analysis of anti-Human CSF2RB (CD131) on TF-1 cells. The 10516-MM10 and 10516-MM01 monoclonal antibodies cross-block binding, suggesting recongnition of overlapping epitopes.
Anti-CD131 Antibody (PE) Alternative Names
Anti-CD131 Antibody;Anti-CDw131 Antibody;Anti-IL3RB Antibody;Anti-IL5RB Antibody;Anti-SMDP5 Antibody
CD131 Background Information

Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

Full Name
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
  • Selleri S, et al. (2008) GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells. J Transl Med. 6:17.
  • Woodcock, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13(21): 5176-85.
  • Dirksen U, et al. (1997) Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression. J Clin Invest. 100(9): 2211-7.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD131 Antibody Rabbit Polyclonal IHC-P 101978-T08
    Anti-CD131 Antibody Rabbit Polyclonal ELISA 10516-RP01
    Anti-CD131 Antibody (PE) Mouse Monoclonal FCM 10516-MM01-P
    Anti-CD131 Antibody Rabbit Monoclonal ELISA 10516-R001
    Anti-CD131 Antibody Mouse Monoclonal FCM 10516-MM01
    Anti-CD131 Antibody (APC) Mouse Monoclonal FCM 10516-MM01-A
    Anti-CD131 Antibody Mouse Monoclonal ELISA 10516-MM11
    Anti-CD131 Antibody Rabbit Polyclonal ELISA 10516-RP02
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