CD13 / ANPEP Protein & Antibody

Cluster of Differentiation 13 / Alanine aminopeptidase

CD13 / ANPEP Protein & Antibody

CD13 / ANPEP Protein, Recombinant

Molecule	Species	Description	Cat. No
CD13/ANPEP	Human	CD13/ANPEP Protein, Recombinant	10051-H08H
CD13/ANPEP	Mouse	CD13/ANPEP Protein, Recombinant	50001-M08H

  10051-H08H:  The specific activity is > 2,500 pmoles / min / µg. Measured by its ability to cleave the fluorogenic peptide substrate, Ala-7-amido-4-methylcoumarin ( Ala-AMC ).

  50001-M08H:  The specific activity is > 800 pmoles / min / µg. Measured by its ability to cleave the fluorogenic peptide substrate, Ala-7-amido-4-methylcoumarin ( Ala-AMC ) .

CD13 / ANPEP Antibody

Molecule	Application	Description	Cat. No
Human CD13/ANPEP	WB, ELISA	CD13/ANPEP Antibody, Rabbit PAb	10051-RP01
Human CD13/ANPEP	WB, ELISA, IHC-P	CD13/ANPEP Antibody, Rabbit PAb (Antigen Affinity Purified)	10051-RP02
Human CD13/ANPEP	WB, ELISA, IHC-P	CD13 / ANPEP Antibody	10051-R122
Human CD13/ANPEP	WB, ELISA	Rabbit Monoclonal Antibody	10051-R123
Mouse CD13/ANPEP	WB, ELISA, IHC-P	CD13/ANPEP Antibody, Rabbit MAb	50001-R101
Mouse CD13/ANPEP	ELISA	Rabbit Polyclonal Antibody	50001-RP01
Mouse CD13/ANPEP	WB, ELISA	Rabbit Polyclonal Antibody	50001-RP02

CD13 / ANPEP Related Areas

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>CD13/ANPEP

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Granulocyte Markers>>CD13/ANPEP

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>CD13/ANPEP

CD13 / ANPEP Alternative Names

CD13, ANPEP, APN, LAP1, GP150, P150, PEPN [Homo sapiens]

Cd13, Apn, Lap-1, Lap1, P150 [Mus musculus]

CD13 / ANPEP Background

Aminopeptidase N (ANPEP or APN), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. It belongs to the peptidase M1 family. CD13 plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases and is involved in the metabolism of regulatory peptides by diverse cell types. CD13/APN is a potent regulator of angiogenesis which is essential for tumor invasion and metastasis, and its transcription in activated endothelial cells is induced by angiogenic growth factors via the RAS/MAPK pathway. In addition, this enzyme has been shown to participate in antigen processing and presentation, and accordingly, defects in this gene appear to be a cause of various types of leukemia or lymphoma and carcinomas.

CD13 / ANPEP Related Studies

1. Pasqualini R, et al. (2000) Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.Cancer Res. 60(3): 722-7.
2. Mabjeesh SJ, et al. (2005) Aminopeptidase N gene expression and abundance in caprine mammary gland is influenced by circulating plasma peptide. J Dairy Sci. 88(6): 2055-64.
3. Dunkel B, et al. (2009) Neutrophil and platelet activation in equine recurrent airway obstruction is associated with increased neutrophil CD13 expression, but not platelet CD41/61 and CD62P or neutrophil-platelet aggregate formation. Vet Immunol Immunopathol. 131(1-2): 25-32.