CD127 Protein & Antibody (IL-7RA)

Cluster of Differentiation 127 (Interleukin 7 Receptor, alpha)

CD127 Products

CD127 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD127/IL-7RA	Human	CD127/IL-7RA/Fc Protein, Recombinant	10975-H03H
CD127/IL-7RA	Human	CD127/IL-7RA Protein, Recombinant	10975-H08H
CD127/IL-7RA	Mouse	CD127/IL-7RA Protein, Recombinant	50090-M08H
CD127/IL-7RA	Rat	IL7R / IL7RA Protein, Recombinant	80083-R05H

CD127 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD127/IL-7RA	WB, ELISA	Mouse Monoclonal Antibody	10975-MM12
Human CD127/IL-7RA	WB, ELISA	CD127/IL-7RA Antibody, Rabbit PAb	10975-RP01
Human CD127/IL-7RA	WB, ELISA	CD127/IL-7RA Antibody, Rabbit PAb (Antigen Affinity Purified)	10975-RP02
Mouse CD127/IL-7RA	WB, ELISA	CD127/IL-7RA Antibody, Rabbit PAb (Antigen Affinity Purified)	50090-RP02

CD127 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD127/IL-7RA	Human	Homo sapiens CD127/IL-7RA cDNA Clone	HG10975-G
CD127/IL-7RA	Mouse	Mus musculus CD127/IL-7RA cDNA Clone	MG50090-M
CD127/IL-7RA	Rat	Rat CD127/IL-7RA cDNA Clone / ORF Clone	RG80083-M

CD127 Related Areas

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD127/IL-7RA

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>CD127/IL-7RA

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD127/IL-7RA

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>CD127/IL-7RA

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells / Regulatory T Cells>>CD127/IL-7RA

CD127 Alternative Names

CD127, IL-7RA, IL7R, IL7RA, CDW127, IL-7R-alpha, ILRA

CD127 Background

Interleukin 7 Receptor alpha (IL-7RA), also known as CD127, is a 75 kDa hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7 receptor alpha (CD127) signaling is essential for T-cell development and regulation of naive and memory T-cell homeostasis. IL-7RA is critically required for the proper development and function of lymphoid cells. Therefore, the IL-7RA is critically required for the proper development and function of lymphoid cells. Studies from both pathogenic and controlled HIV infection indicate that the containment of immune activation and preservation of CD127 expression are critical to the stability of CD4(+) T cells in infection. A better understanding of the factors regulating CD127 expression in HIV disease, particularly on T(CM) cells, might unveil new approaches exploiting the IL-7/IL-7R receptor pathway to restore T cell homeostasis and promote immune reconstitution in HIV infection. Factors relevant to HIV infection that could potentially decrease CD127 expression on human CD8(+) T cells. CD127 down-regulation may be an important contributor to HIV-associated T-cell dysfunction. In addition to IL-7, IL-7RA also associates with TSLPR to form the functional receptor for thymic stromal lymphopoietin (TSLP) which indirectly regulates T cell development by modulating dendritic cell activation. Mutations in the human IL-7RA gene cause a type of severe combined immunodeficiency in which the major deficiencies are in T cell development, whereas B and NK cells are relatively normal in number. Variation in the IL7RA gene was recently found associated with multiple sclerosis (MS). The polymorphisms in the IL7RA gene is involved in MS pathogenesis and suggest that IL7RA variation may primarily affect chronic disease courses. Soluble CD127 (sCD127) appears to play an important role in the immunopathogenesis of several chronic infections, multiple sclerosis, and various cancers.

CD127 Related Studies

Vranjkovic A, et al. (2007) IL-7 decreases IL-7 receptor alpha (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. Int Immunol. 19(12): 1329-39.
Kiazyk SA, et al. (2008) Loss of CD127 expression links immune activation and CD4(+) T cell loss in HIV infection. Trends Microbiol. 16(12): 567-73.
Akkad DA, et al. (2009) Variation in the IL7RA and IL2RA genes in German multiple sclerosis patients. J Autoimmun. 32(2): 110-5.
Crawley AM, et al. (2010) Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection. J Immunol. 184(9): 4679-87.