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CD127 / IL-7RA Antibody, Rabbit PAb, Antigen Affinity Purified

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    Mouse IL7RA/CD127 Antibody Product Information
    Immunogen:Recombinant Mouse CD127 / IL-7RA protein (Catalog#50090-M08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Mouse CD127 / IL-7RA (rM CD127 / IL-7RA; Catalog#50090-M08H; NP_032398.3; Met 1-Asp 239). CD127 / IL-7RA specific IgG was purified by Mouse CD127 / IL-7RA affinity chromatography.
    Other IL7RA/CD127 Antibody Products
    Reactivity: Human  
    Application: FCM  
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    10975-R014-F-25
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    Reactivity: Human  
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    10975-R001-C-25
    10975-R001-C-100
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    Reactivity: Human  
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    • Slide 1
    10975-R001-P-25
    10975-R001-P-100
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    Reactivity: Human  
    Application: FCM  
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    10975-R014-P-25
    10975-R014-P-100
    25 Test 
    100 Tests 
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    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10975-R014-50
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    50 µg 
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    Reactivity: Human  
    Application: ELISA  
      10975-MM12-50
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      50 µg 
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      Reactivity: Human  
      Application: ELISA  WB  
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      10975-T48-50
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      10975-T48-100
      50 µg 
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      Reactivity: Human  
      Application: ELISA  FCM  
      • Slide 1
      10975-R001-50
      10975-R001-100
      50 µg 
      100 µg 
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      Reactivity: Human  
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      10975-R001-A-25
      10975-R001-A-100
      25 Test 
      100 Tests 
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      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10975-R001-F-25
      10975-R001-F-100
      25 Test 
      100 Tests 
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      Reactivity: Mouse  
      Application: 
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      50090-T52-50
      50090-T52-200
      50090-T52-100
      50 µg 
      200 µg 
      100 µg 
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      Reactivity: Mouse  
      Application: ELISA  
        50090-R115-50
        50090-R115-100
        50 µg 
        100 µg 
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        Reactivity: Mouse  
        Application: ELISA  
          50090-RP01-400
          50090-RP01-200
          50090-RP01-100
          400 µg 
          200 µg 
          100 µg 
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          Reactivity: Rat  
          Application: ELISA  
            80083-RP01-400
            80083-RP01-200
            80083-RP01-100
            400 µg 
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            Reactivity: Rat  
            Application: ELISA  
              80083-T16-50
              80083-T16-200
              80083-T16-100
              50 µg 
              200 µg 
              100 µg 
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              Reactivity: Cynomolgus  
              Application: ELISA  
                90332-RP01-400
                90332-RP01-200
                90332-RP01-100
                400 µg 
                200 µg 
                100 µg 
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                IL7R/IL-7R/CD127 Background

                Interleukin 7 Receptor alpha (IL-7RA), also known as CD127, is a 75 kDa hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7 receptor alpha (CD127) signaling is essential for T-cell development and regulation of naive and memory T-cell homeostasis. IL-7RA is critically required for the proper development and function of lymphoid cells. Therefore, the IL-7RA is critically required for the proper development and function of lymphoid cells. Studies from both pathogenic and controlled HIV infection indicate that the containment of immune activation and preservation of CD127 expression are critical to the stability of CD4(+) T cells in infection. A better understanding of the factors regulating CD127 expression in HIV disease, particularly on T(CM) cells, might unveil new approaches exploiting the IL-7/IL-7R receptor pathway to restore T cell homeostasis and promote immune reconstitution in HIV infection. Factors relevant to HIV infection that could potentially decrease CD127 expression on human CD8(+) T cells. CD127 down-regulation may be an important contributor to HIV-associated T-cell dysfunction. In addition to IL-7, IL-7RA also associates with TSLPR to form the functional receptor for thymic stromal lymphopoietin (TSLP) which indirectly regulates T cell development by modulating dendritic cell activation. Mutations in the human IL-7RA gene cause a type of severe combined immunodeficiency in which the major deficiencies are in T cell development, whereas B and NK cells are relatively normal in number. Variation in the IL7RA gene was recently found associated with multiple sclerosis (MS). The polymorphisms in the IL7RA gene is involved in MS pathogenesis and suggest that IL7RA variation may primarily affect chronic disease courses. Soluble CD127 (sCD127) appears to play an important role in the immunopathogenesis of several chronic infections, multiple sclerosis, and various cancers.

                Mouse IL7R/IL-7R/CD127 References
              • Vranjkovic A, et al. (2007) IL-7 decreases IL-7 receptor alpha (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. Int Immunol. 19(12): 1329-39.
              • Kiazyk SA, et al. (2008) Loss of CD127 expression links immune activation and CD4(+) T cell loss in HIV infection. Trends Microbiol. 16(12): 567-73.
              • Akkad DA, et al. (2009) Variation in the IL7RA and IL2RA genes in German multiple sclerosis patients. J Autoimmun. 32(2): 110-5.
              • Crawley AM, et al. (2010) Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection. J Immunol. 184(9): 4679-87.
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                Catalog: 50090-RP02-50
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                Datasheet & Documentation

                All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"