Anti-IL7R alpha Antibody

Cat: 10975-RP02
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All IL7R alpha Reagents
Anti-IL7R alpha Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL7R alpha Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IL7R alpha
Immunogen
Recombinant Human IL7RA protein (Catalog#10975-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human IL7RA (rh IL7RA; Catalog#10975-H08H; NP_002176.2; Met 1-Gly 236). IL7RA specific IgG was purified by human IL7RA affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL7R alpha Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 0.1-0.2 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL7R alpha Antibody Alternative Names
Anti-CD127 Antibody;Anti-CDW127 Antibody;Anti-IL-7R Antibody;Anti-IL-7R-alpha Antibody;Anti-IL7RA Antibody;Anti-ILRA Antibody
IL7R alpha Background Information

Interleukin 7 Receptor alpha (IL-7RA), also known as CD127, is a 75 kDa hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7 receptor alpha (CD127) signaling is essential for T-cell development and regulation of naive and memory T-cell homeostasis. IL-7RA is critically required for the proper development and function of lymphoid cells. Therefore, the IL-7RA is critically required for the proper development and function of lymphoid cells. Studies from both pathogenic and controlled HIV infection indicate that the containment of immune activation and preservation of CD127 expression are critical to the stability of CD4(+) T cells in infection. A better understanding of the factors regulating CD127 expression in HIV disease, particularly on T(CM) cells, might unveil new approaches exploiting the IL-7/IL-7R receptor pathway to restore T cell homeostasis and promote immune reconstitution in HIV infection. Factors relevant to HIV infection that could potentially decrease CD127 expression on human CD8(+) T cells. CD127 down-regulation may be an important contributor to HIV-associated T-cell dysfunction. In addition to IL-7, IL-7RA also associates with TSLPR to form the functional receptor for thymic stromal lymphopoietin (TSLP) which indirectly regulates T cell development by modulating dendritic cell activation. Mutations in the human IL-7RA gene cause a type of severe combined immunodeficiency in which the major deficiencies are in T cell development, whereas B and NK cells are relatively normal in number. Variation in the IL7RA gene was recently found associated with multiple sclerosis (MS). The polymorphisms in the IL7RA gene is involved in MS pathogenesis and suggest that IL7RA variation may primarily affect chronic disease courses. Soluble CD127 (sCD127) appears to play an important role in the immunopathogenesis of several chronic infections, multiple sclerosis, and various cancers.

Full Name
interleukin 7 receptor
References
  • Vranjkovic A, et al. (2007) IL-7 decreases IL-7 receptor alpha (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. Int Immunol. 19(12): 1329-39.
  • Kiazyk SA, et al. (2008) Loss of CD127 expression links immune activation and CD4(+) T cell loss in HIV infection. Trends Microbiol. 16(12): 567-73.
  • Akkad DA, et al. (2009) Variation in the IL7RA and IL2RA genes in German multiple sclerosis patients. J Autoimmun. 32(2): 110-5.
  • Crawley AM, et al. (2010) Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection. J Immunol. 184(9): 4679-87.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-IL7R alpha Antibody Rabbit Monoclonal FCM 10975-R014
    Anti-IL7R alpha Antibody (PE) Rabbit Monoclonal FCM 10975-R001-P
    Anti-IL7R alpha Antibody (FITC) Rabbit Monoclonal FCM 10975-R014-F
    Anti-IL7R alpha Antibody (APC) Rabbit Monoclonal FCM 10975-R014-A
    Anti-IL7R alpha Antibody (PerCP) Rabbit Monoclonal FCM 10975-R001-C
    Anti-IL7R alpha Antibody (APC) Rabbit Monoclonal FCM 10975-R001-A
    Anti-IL7R alpha Antibody Rabbit Monoclonal ELISA,FCM 10975-R001
    Anti-IL7R alpha Antibody (PE) Rabbit Monoclonal FCM 10975-R014-P
    Anti-IL7R alpha Antibody Rabbit Polyclonal WB,ELISA 10975-T48
    Anti-IL7R alpha Antibody Mouse Monoclonal ELISA 10975-MM12
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