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IL3RA/CD123  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
  • Slide 1
10518-H08H-50
10518-H08H-20
50 µg 
20 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
10518-H03H-50
10518-H03H-20
50 µg 
20 µg 
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Expression host: Human Cells  
  • Slide 1
50810-M02H-20
50810-M02H-100
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
50810-M08H-50
50810-M08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
70077-D08H-20
70077-D08H-10
20 µg 
10 µg 
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IL3RA/CD123 Related Area

IL3RA/CD123 Related Pathways

    IL3RA/CD123 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    IL3RA/CD123 Summary & Protein Information

    IL3RA/CD123 Background

    Gene Summary: The protein encoded by IL3RA gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. IL3RA gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    Subunit structure: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
    Subcellular location: Membrane; Single-pass type I membrane protein.
    Sequence similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily.
    General information above from UniProt

    Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily. The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. The WSXWS motif of IL3RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box one motif of IL3RA is required for JAK interaction and / or activation. IL3RA represents a unique marker for primitive leukemic stem cells. Targeting of IL3RA may be a promising strategy for the preferential ablation of AML cells. Aberrant IL3RA expression is a good marker for monitoring of minimal residual disease. IL3RA is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis. CD123 was highly expressed in the bone marrow of the patients with myelodysplastic syndrome (MDS), significantly correlated with the proportion of bone marrow blasts, and thus might be the marker of MDS malignant clone. IL3RA is also a useful new marker for distinguishing B-cell disorders with circulating villous lymphocytes as its expression is characteristic of typical hairy cell leukemia (HCL) with high sensitivity and specificity.

    IL3RA/CD123 Alternative Name

    IL3R,CD123,IL3RX,IL3RY,IL3RAY,hIL-3Ra, [homo-sapiens]
    CD123,hIL-3Ra,IL3R,IL3RA,IL3RAY,IL3RX,IL3RY,MGC34174,RP11-261P4.2, [human]
    CD123,CDw123,Il3ra,SUT-1, [mouse]
    CD123,SUT-1,CDw123, [mus-musculus]

    IL3RA/CD123 Related Studies

  • Del Giudice I, et al. (2004) The diagnostic value of CD123 in B-cell disorders with hairy or villous lymphocytes. Haematologica. 89(3): 303-8.
  • Du X, et al. (2007) New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells. J Immunother. 30(6): 607-13.
  • Yue LZ, et al. (2010) Expression of CD123 and CD114 on the bone marrow cells of patients with myelodysplastic syndrome. Chin Med J (Engl). 123(15): 2034-2037.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"