CD123 Protein & Antibody (IL3RA)

Cluster of Differentiation 123 (Interleukin 3 Receptor, Alpha)

CD123 Products

CD123 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD123/IL3RA	Human	CD123/IL3RA/Fc Protein, Recombinant	10518-H03H
CD123/IL3RA	Human	CD123/IL3RA Protein, Recombinant	10518-H08H

10518-H03H: Immobilized human IL3 at 20 µg/ml (100 µl/well) can bind human IL3RA with a linear ranger of 0.064-1.6 µg/ml. Measured by its binding ability in a functional ELISA.

10518-H08H: Immobilized human IL3 at 20 µg/ml (100 µl/well) can bind biotinylated human IL3RA with a linear ranger of 0.32-1.6 µg/ml. Measured by its binding ability in a functional ELISA.

CD123 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD123/IL3RA	ELISA	CD123/IL3RA Antibody, Rabbit MAb	10518-R012
Human CD123/IL3RA	WB	CD123/IL3RA Antibody, Rabbit MAb	10518-R017
Human CD123/IL3RA	WB	CD123/IL3RA Antibody, Mouse MAb	10518-MM07
Human CD123/IL3RA	WB	CD123/IL3RA Antibody, Mouse MAb	10518-MM11

CD123 Elisa Pair Set

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD123/IL3RA	ELISA	CD123 Elisa Pair Set	SEK10518

CD123 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD123/IL3RA	Human	Human CD123/IL3RA cDNA Clone / ORF Clone	HG10518-M
CD123/IL3RA	Mouse	Mouse CD123/IL3RA cDNA Clone / ORF Clone	MG50810-G
CD123/IL3RA	Canine	Canine IL3RA Gene cDNA Clone / ORF Clone	DG70077-G

CD123 Related Areas

Cancer>>Cancer Stem Cell (CSC)>>CD123/IL3RA

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>CD123/IL3RA

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>CD123/IL3RA

CD123 Alternative Names

CD123, IL3RA, RP11-261P4.2, CD123, IL3R, IL3RAY, IL3RX, IL3RY, MGC34174, hIL-3Ra [Homo sapiens]

CD123, Il3ra, CDw123, SUT-1 [Mus musculus]

CD123 Background

Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily. The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. The WSXWS motif of IL3RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box one motif of IL3RA is required for JAK interaction and / or activation. IL3RA represents a unique marker for primitive leukemic stem cells. Targeting of IL3RA may be a promising strategy for the preferential ablation of AML cells. Aberrant IL3RA expression is a good marker for monitoring of minimal residual disease. IL3RA is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis. CD123 was highly expressed in the bone marrow of the patients with myelodysplastic syndrome (MDS), significantly correlated with the proportion of bone marrow blasts, and thus might be the marker of MDS malignant clone. IL3RA is also a useful new marker for distinguishing B-cell disorders with circulating villous lymphocytes as its expression is characteristic of typical hairy cell leukemia (HCL) with high sensitivity and specificity.

CD123 Related Studies

Del Giudice I, et al. (2004) The diagnostic value of CD123 in B-cell disorders with hairy or villous lymphocytes. Haematologica. 89(3): 303-8.
Du X, et al. (2007) New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells. J Immunother. 30(6): 607-13.
Yue LZ, et al. (2010) Expression of CD123 and CD114 on the bone marrow cells of patients with myelodysplastic syndrome. Chin Med J (Engl). 123(15): 2034-2037.