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> CD122 Protein (IL-2RB Protein) CD122 Protein (IL-2RB Protein)
Cluster of Differentiation 122 (Interleukin 2 Receptor beta)
CD122 Products
CD122 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| CD122/IL-2RB | Human | CD122/IL-2RB/Fc Protein, Recombinant | 10696-H02H |
| CD122/IL-2RB | Human | CD122/IL-2RB Protein, Recombinant | 10696-HCCH |
CD122 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| CD122/IL-2RB | Human | Homo sapiens CD122/ IL-2RB cDNA Clone(NM_000878.2) | HG10696-M |
| CD122/IL-2RB | Mouse | Mouse CD122/IL2RB cDNA Clone / ORF Clone | MG50792-G |
| CD122/IL-2RB | Canine | Canine IL2RB Gene cDNA Clone / ORF Clone | DG70082-G |
| CD122/IL-2RB | Rat | Rat IL2RB cDNA Clone / ORF Clone | RG80340-G |
CD122 Related Areas
Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD122/IL-2RB
Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>CD122/IL-2RB
Immunology>>Cluster of Differentiation>>B Cell CD Antigen>> CD122/IL-2RB
Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>other>> CD122/IL-2RB
Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>> CD122/IL-2RB
Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells / Regulatory T Cells>>CD122/IL-2RB
CD122 Alternative Names
CD122, IL-2RB, IL2RB, RP5-1170K4.6, P70-75
CD122 Background
Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.
CD122 Related Studies
- Foss F. (2006) Clinical experience with denileukin diftitox (ONTAK). Semin Oncol. 33(1 Suppl 3): 11-6.
- Sprent J, et al. (2001) T cell death and memory. Science. 293(5528): 245-8.
- Teshigawara K, et al. (1987) Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med. 165 (1): 223-38.
