CD122 Protein (IL-2RB Protein)

Cluster of Differentiation 122 (Interleukin 2 Receptor beta)

CD122 Products

CD122 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD122/IL-2RB	Human	CD122/IL-2RB/Fc Protein, Recombinant	10696-H02H
CD122/IL-2RB	Human	CD122/IL-2RB Protein, Recombinant	10696-HCCH

CD122 cDNA Clone

Molecule	Species	Description	Cat. No
CD122/IL-2RB	Human	Homo sapiens CD122/ IL-2RB cDNA Clone(NM_000878.2)	HG10696-M
CD122/IL-2RB	Mouse	CD122/IL2RB cDNA Clone / ORF Clone	MG50792-G
CD122/IL-2RB	Rat	IL2RB cDNA Clone / ORF Clone	RG80340-G

 CD122 Related Areas

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD122/IL-2RB

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>CD122/IL-2RB

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>> CD122/IL-2RB

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>other>> CD122/IL-2RB

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>> CD122/IL-2RB

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells / Regulatory T Cells>>CD122/IL-2RB

CD122 Alternative Names

CD122, IL-2RB, IL2RB, RP5-1170K4.6, P70-75

CD122 Background

Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.

CD122 Related Studies

1. Foss F. (2006) Clinical experience with denileukin diftitox (ONTAK). Semin Oncol. 33(1 Suppl 3): 11-6.
2. Sprent J, et al. (2001) T cell death and memory. Science. 293(5528): 245-8.
3. Teshigawara K, et al. (1987) Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med. 165 (1): 223-38.