All GM-CSF Receptor alpha reagents are produced in house and quality controlled, including 10 GM-CSF Receptor alpha Antibody, 1 GM-CSF Receptor alpha Gene, 2 GM-CSF Receptor alpha Lysate, 2 GM-CSF Receptor alpha Protein. All GM-CSF Receptor alpha reagents are ready to use.
Recombinant GM-CSF Receptor alpha proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
GM-CSF Receptor alpha antibodies are validated with different applications, which are FCM, ELISA.
GM-CSF Receptor alpha cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each GM-CSF Receptor alpha of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CD116/GM-CSFR has been preferentially associated with M4, M5 subtype of AML but is not specific. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD116/GM-CSFR is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. CD116/GM-CSFR is found in the pseudoautosomal region (PAR) of the X and Y chromosomes.
GM-CSF Receptor alpha References
Sjöblom C, et al. (2002) Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts independently of the beta common subunit of the GM-CSF receptor to prevent inner cell mass apoptosis in human embryos. Biol Reprod. 67(6): 1817-23.
Goldstein JI, et al. (2011) Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology. 141(1): 208-16.
Saulle E, et al. (2009) Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation. Br J Haematol. 145(3): 399-411.