CD116 Protein & Antibody (GM-CSFR)

Cluster of Differentiation 116 (Granulocyte-Macrophage Colony-Stimulating Factor Receptor)

CD116 Products

CD116 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD116/GM-CSFR	Human	CD116/GM-CSFR/Fc Protein, Recombinant	10701-H02H
CD116/GM-CSFR	Human	CD116/GM-CSFR Protein, Recombinant	10701-H08H

  10701-H02H : ED₅₀ = 10 - 15 ug / ml .Measured by its ability to inhibit GM-CSF dependent proliferation of TF-1 human erythroleukemic cells.

  10701-H08H : ED₅₀ = 3 - 5 ug / ml.Measured by its ability to inhibit GM-CSF dependent proliferation of TF-1 human erythroleukemic cells.

CD116 Antibody

Molecule	Application	Description	Cat. No
Human CD116/GM-CSFR	WB, ELISA	Mouse Monoclonal Antibody	10701-MM01
Human CD116/GM-CSFR	WB, ELISA	Rabbit Monoclonal Antibody	10701-R015
Human CD116/GM-CSFR	WB, ELISA	Rabbit Polyclonal Antibody	10701-RP01
Human CD116/GM-CSFR	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10701-RP02

CD116 Alternative Names

CD116, GM-CSFR, Csfgmra, GM-CSF-Ra, Csf2ra

CD116 Related Areas

Cancer>>Growth Factor & Receptor>>CSF & Receptor>>CD116/GM-CSFR

Immunology>>Cytokine & Receptor>>CSF & Receptor>>CD116/GM-CSFR

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-6 Family Signaling Related Molecules>>CD116/GM-CSFR

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Granulocyte Markers / Neutrophils>>CD116/GM-CSFR

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>CD116/GM-CSFR

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>CD116/GM-CSFR

CD116 Background

CD116/GM-CSFR has been preferentially associated with M4, M5 subtype of AML but is not specific. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD116/GM-CSFR is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. CD116/GM-CSFR is found in the pseudoautosomal region (PAR) of the X and Y chromosomes.

CD116 Related Studies

1. Sjöblom C, et al. (2002) Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts independently of the beta common subunit of the GM-CSF receptor to prevent inner cell mass apoptosis in human embryos. Biol Reprod. 67(6): 1817-23.
2. Goldstein JI, et al. (2011) Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology. 141(1): 208-16.
3. Saulle E, et al. (2009) Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation. Br J Haematol. 145(3): 399-411.