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CSF2RA / GM-CSFR / CD116 Antibody, Mouse MAb

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    Human GM-CSFR Antibody Product Information
    Immunogen:Recombinant Human CD116 protein (Catalog#10701-H08H)
    Clone ID:4A4B3A2
    Ig Type:Mouse IgG1
    Concentration:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD116 / GM-CSFR (rh CD116; Catalog#10701-H08H; NP_034100.2; Met 1-Gly 320). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography
    Other GM-CSFR Antibody Products
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10701-MM03-P-25
    10701-MM03-P-100
    25 Test 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10701-RP01-400
      10701-RP01-200
      10701-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10701-R009-A-25
      10701-R009-A-100
      25 Test 
      100 Tests 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10701-R015-50
        10701-R015-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  FCM  
        • Slide 1
        10701-R009-50
        10701-R009-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        • Slide 1
        10701-R009-F-25
        10701-R009-F-100
        25 Test 
        100 Tests 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10701-RP02-50
          10701-RP02-200
          10701-RP02-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          • Slide 1
          10701-R009-P-25
          10701-R009-P-100
          25 Test 
          100 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10701-MM03-50
          10701-MM03-200
          10701-MM03-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          CD116/GM-CSFR Background

          CD116/GM-CSFR has been preferentially associated with M4, M5 subtype of AML but is not specific. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD116/GM-CSFR is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. CD116/GM-CSFR is found in the pseudoautosomal region (PAR) of the X and Y chromosomes.

          Human CD116/GM-CSFR References
        • Sjöblom C, et al. (2002) Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts independently of the beta common subunit of the GM-CSF receptor to prevent inner cell mass apoptosis in human embryos. Biol Reprod. 67(6): 1817-23.
        • Goldstein JI, et al. (2011) Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology. 141(1): 208-16.
        • Saulle E, et al. (2009) Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation. Br J Haematol. 145(3): 399-411.
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          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"