Anti-GM-CSF Receptor alpha Antibody

Cat: 10701-RP01
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Anti-GM-CSF Receptor alpha Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-GM-CSF Receptor alpha Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human GM-CSF Receptor alpha
Immunogen
Recombinant Human CD116 protein (Catalog#10701-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CD116 / GM-CSFR (rh GM-CSFR; Catalog#10701-H08H; NP_034100.2; Met 1-Gly 320). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-GM-CSF Receptor alpha Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-GM-CSF Receptor alpha Antibody Alternative Names
Anti-CD116 Antibody;Anti-CDw116 Antibody;Anti-CSF2R Antibody;Anti-CSF2RAX Antibody;Anti-CSF2RAY Antibody;Anti-CSF2RX Antibody;Anti-CSF2RY Antibody;Anti-GM-CSF-R-alpha Antibody;Anti-GMCSFR Antibody;Anti-GMR Antibody;Anti-SMDP4 Antibody
GM-CSF Receptor alpha Background Information

CD116/GM-CSFR has been preferentially associated with M4, M5 subtype of AML but is not specific. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD116/GM-CSFR is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. CD116/GM-CSFR is found in the pseudoautosomal region (PAR) of the X and Y chromosomes.

Full Name
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
References
  • Sjöblom C, et al. (2002) Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts independently of the beta common subunit of the GM-CSF receptor to prevent inner cell mass apoptosis in human embryos. Biol Reprod. 67(6): 1817-23.
  • Goldstein JI, et al. (2011) Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology. 141(1): 208-16.
  • Saulle E, et al. (2009) Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation. Br J Haematol. 145(3): 399-411.
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