CD113 Protein & Antibody (Nectin-3)

Cluster of Differentiation 113

CD113 Products

CD113 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD113/Nectin-3	Human	CD113/Nectin-3, Recombinant Protein	10852-H08H

  10852-H08H:

1. Immobilized recombinant human PVRL3 at 1µg/mL (100µl/well) can bind biotinylated Nectin-1 with a linear range of 6.4–800 ng/ml. Measured by its binding ability in a functional ELISA.

2. Immobilized recombinant human PVRL3 at 1µg/mL (100µl/well) can bind Nectin-1/ Fc chimera with a linear range of 0.156–5 ng/ml. Measured by its binding ability in a functional ELISA.

CD113 Antibody

Molecule	Application	Description	Cat. No
Human CD113/Nectin-3	WB, ELISA	Rabbit Polyclonal Antibody	10852-RP01
Human CD113/Nectin-3	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10852-RP02

CD113 cDNA Clone

Molecule	Species	Description	Cat. No
CD113/Nectin-3	Human	Homo sapiens CD113/Nectin-3 cDNA Clone	HG10852-M

CD113 Alternative Names

CD113, Nectin-3, PVRL3, CDw113, DKFZp566B0846, FLJ90624, PPR3, PRR3, PVRR3

CD113 Related Areas

Neuroscience>>Synaptic Protein>>CD113/Nectin-3

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM) >>CD113/Nectin-3

Immunology>>Cluster of Differentiation>>Other>>CD113/Nectin-3

CD113 Background

Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest). It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.

CD113 Related Studies

1. Satoh-Horikawa, et al. (2000). Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J Biol Chem (UNITED STATES) . 275 (14): 10291-9.
2. Reymond N, et al. (2000). Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. Gene (NETHERLANDS). 255 (2): 347-55.