Anti-Nectin 3 Antibody

Cat: 10852-MM04
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Anti-Nectin 3 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Nectin 3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Nectin 3
Immunogen
Recombinant Human CD113 / Nectin-3 / PVRL3 Protein (Catalog#10852-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD113 / Nectin-3 / PVRL3 (rh CD113 / Nectin-3 / PVRL3; Catalog#10852-H08H; NP_056295.1; Met1-Asp400). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #04
Purification
Protein A
Formulation
PBS, 5% Trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Nectin 3 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Nectin 3 Antibody Alternative Names
Anti-CD113 Antibody;Anti-CDw113 Antibody;Anti-DKFZp566B0846 Antibody;Anti-FLJ90624 Antibody;Anti-nectin-3 Antibody;Anti-PPR3 Antibody;Anti-PRR3 Antibody;Anti-PVRL3 Antibody;Anti-PVRR3 Antibody
Nectin 3 Background Information

Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest). It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.

Full Name
poliovirus receptor-related 3
References
  • Satoh-Horikawa, et al. (2000). Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J Biol Chem (UNITED STATES) . 275 (14): 10291-9.
  • Reymond N, et al. (2000). Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. Gene (NETHERLANDS). 255 (2): 347-55.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Nectin 3 Antibody Mouse Monoclonal IHC-P 10852-MM02
    Anti-Nectin 3 Antibody Rabbit Polyclonal WB,ELISA 10852-RP02
    Anti-Nectin 3 Antibody Rabbit Polyclonal ELISA 10852-T16
    Anti-Nectin 3 Antibody Rabbit Polyclonal ELISA 10852-RP01
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