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CD112/Nectin-2/PVRL2  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
  • Slide 1
10005-H02H-50
10005-H02H-100
50 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
10005-H08H-50
10005-H08H-100
50 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
10005-HCCH-50
10005-HCCH-100
50 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
50318-M08H-50
50318-M08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
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80327-R08H-50
80327-R08H-100
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100 µg 
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Expression host: Human Cells  
  • Slide 1
90206-C08H-50
90206-C08H-100
50 µg 
100 µg 
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CD112/Nectin-2/PVRL2 Related Area

CD112/Nectin-2/PVRL2 Related Pathways

    CD112/Nectin-2/PVRL2 Summary & Protein Information

    CD112/Nectin-2/PVRL2 Background

    Gene Summary: This PVRL2 gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. Nectin-2 is one of the plasma membrane components of adherens junctions. Nectin-2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
    General information above from NCBI
    Subunit structure: Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses.
    Subcellular location: Cell membrane; Single-pass type I membrane protein.
    Tissue specificity: Ubiquitous.
    Sequence similarity: Belongs to the nectin family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.C
    General information above from UniProt

    Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

    CD112/Nectin-2/PVRL2 Alternative Name

    CD112/Nectin-2/PVRL2 Related Studies

  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
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