Anti-Nectin-2 Antibody

Cat: 10005-MM11
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All Nectin-2 Reagents
Anti-Nectin-2 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Nectin-2 Antibody
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human Nectin-2
Immunogen
Recombinant Human CD112 protein (Catalog#10005-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD112 / Nectin-2 / PVRL2 (rh CD112 / Nectin-2 / PVRL2; Catalog#10005-H08H; Met 1-Leu 360; NP_002847.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #11
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Nectin-2 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
FCM 0.5-2 μg/Test  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Nectin-2 Antibody (Mouse Monoclonal antibody) Images
Human CD112/Nectin-2/PVRL2 Flow Cytometry (FC) 5432
Flow cytometric analysis of anti-CD112 on A549 cells. A549 cells were detached using 1X trypsin, washed, then stained with purified mouse anti-CD112 (10005-MM11). Second step staining with goat anti-mouse IgG FC polyclonal antibody.
Anti-Nectin-2 Antibody Alternative Names
Anti-CD112 Antibody;Anti-HVEB Antibody;Anti-Nectin-2 Antibody;Anti-PRR2 Antibody;Anti-PVRR2 Antibody
Nectin-2 Background Information

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

Full Name
poliovirus receptor-related 2 (herpesvirus entry mediator B)
References
  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Nectin-2 Antibody Rabbit Monoclonal ELISA 80327-R013
    Anti-Nectin-2 Antibody Rabbit Polyclonal ELISA 80327-RP01
    Anti-Nectin-2 Antibody Rabbit Polyclonal ELISA,IHC-P 80327-T24
    Anti-Nectin-2 Antibody Rabbit Polyclonal ELISA 50318-RP02
    Anti-Nectin-2 Antibody Rabbit Polyclonal ELISA 50318-RP01
    Anti-Nectin-2 Antibody Rabbit Monoclonal WB,ELISA,IP 50318-R110
    Anti-Nectin-2 Antibody Mouse Monoclonal ELISA 10005-MM01
    Anti-Nectin-2 Antibody (PE) Rabbit Monoclonal FCM 10005-R005-P
    Anti-Nectin-2 Antibody Rabbit Monoclonal ELISA,ELISA(Cap),FCM 10005-R005
    Anti-Nectin-2 Antibody Rabbit Polyclonal WB,ELISA,IP 10005-RP04
    Anti-Nectin-2 Antibody Rabbit Monoclonal ELISA 10005-R017
    Anti-Nectin-2 Antibody Rabbit Polyclonal ELISA 10005-RP03
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