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CD112 / Nectin-2 / PVRL2 Antibody, Rabbit MAb

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    Human PVRL2/CD112 Antibody Product Information
    Immunogen:Recombinant Human CD112 protein (Catalog#10005-H08H)
    Clone ID:017
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human CD112 extracellular domain (rh CD112; Catalog#10005-H08H; Met 1-Leu 360; NP_002847.1).
    Other PVRL2/CD112 Antibody Products
    CD112/Nectin-2/PVRL2 Background

    Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

    Human CD112/Nectin-2/PVRL2 References
  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
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    Catalog: 10005-R017-50
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    100 µg
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    Datasheet & Documentation

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"