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CD112 / Nectin-2 / PVRL2 Antibody, Rabbit MAb

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  • CD112 / Nectin-2 / PVRL2 Antibody, Rabbit MAb, Western blot
  • CD112 / Nectin-2 / PVRL2 Antibody, Rabbit MAb, Immunoprecipitation
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Mouse PVRL2/CD112 Antibody Product Information
Immunogen:Recombinant Mouse PVRL2 protein (Catalog#50318-M08H)
Clone ID:110
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PVRL2 extracellular domain (rM PVRL2; Catalog#50318-M08H; NP_033016.3; Met 1-Gly 351).
Mouse PVRL2/CD112 Antibody WB Application Image
Mouse PVRL2/CD112 Antibody IP Application Image
Other PVRL2/CD112 Antibody Products
Immunochemical staining of human CCNF in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
CD112/Nectin-2/PVRL2 Background

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

Mouse CD112/Nectin-2/PVRL2 References
  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
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