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CD112 / Nectin-2 / PVRL2 Antibody, Rabbit PAb

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    Human PVRL2/CD112 Antibody Product Information
    Immunogen:Recombinant Human CD112 / Nectin2 protein (Catalog#10005-H08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Human CD112 / Nectin2 extracellular domain (rhCD112; Catalog#10005-H08H; Met 1-Leu 360; NP_002847.1). Total IgG was purified by Protein A affinity chromatography.
    Other PVRL2/CD112 Antibody Products
    CD112/Nectin-2/PVRL2 Background

    Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

    Human CD112/Nectin-2/PVRL2 References
  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
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    Catalog: 10005-RP03-400
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    Datasheet & Documentation

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