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CD111/Nectin-1/PVRL1  Antibody

All PVRL1 Reagents

Reactivity: Human  
Application: FCM  
11611-MM09-50
11611-MM09-200
11611-MM09-100
50 µg 
200 µg 
100 µg 
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  • Slide 1
Reactivity: Human  
Application: FCM  
11611-MM09-P-25
11611-MM09-P-100
25 Test 
100 Tests 
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  • Slide 1
  • Slide 1
Reactivity: Human  
Application: ELISA  
11611-RP02-50
11611-RP02-200
11611-RP02-100
50 µg 
200 µg 
100 µg 
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    Reactivity: Human  
    Application: FCM  
    11611-MM09-A-25
    11611-MM09-A-100
    25 Test 
    100 Tests 
    Add to Cart
    • Slide 1
    Reactivity: Human  
    Application: ELISA  
    11611-MM01-50
    11611-MM01-200
    11611-MM01-100
    50 µg 
    200 µg 
    100 µg 
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      Reactivity: Human  
      Application: ELISA  WB  
      11611-RP01-400
      11611-RP01-200
      11611-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      • Slide 1
      Reactivity: Rat  
      Application: 
      80244-R029-50
      80244-R029-100
      80244-R029-1
      50 µg 
      100 µg 
      1 mg 
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        Reactivity: Rat  
        Application: ELISA  
        80244-T16-50
        80244-T16-200
        80244-T16-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
          Reactivity: Rat  
          Application: ELISA  
          80244-RP01-400
          80244-RP01-200
          80244-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart
            Reactivity: Rat  
            Application: ELISA  
            80244-R004-50
            80244-R004-100
            80244-R004-1
            50 µg 
            100 µg 
            1 mg 
            Add to Cart

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              CD111/Nectin-1/PVRL1 Related Area

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                CD111/Nectin-1/PVRL1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

                CD111/Nectin-1/PVRL1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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                CD111/Nectin-1/PVRL1 Summary & Protein Information

                CD111/Nectin-1/PVRL1 Background

                Gene Summary: This PVRL1 gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. Nectin-1 is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. Nectin-1 acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this PVRL gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
                General information above from NCBI
                Subunit structure: Interacts (via Ig-like C2-type domain 2) with FGFR1, FGFR2 and FGFR3 (By similarity). Cis- and trans-homodimer. Can form trans-heterodimers with PVRL3/nectin-3 and with PVRL4/nectin-4. Interaction between PVRL1 and PVRL3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via cytoplasmic domain) with MLLT4/afadin (via PDZ domain); this interaction recruits PVRL1 to cadherin-based adherens junctions and provides a connection with the actin cytoskeleton. Interacts with integrin alphaV/beta3. Interacts with herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses. {ECO:0000250, ECO:0000269|PubMed:10225955, ECO:0000269|PubMed:11544254, ECO:0000269|PubMed:16679515, ECO:0000269|PubMed:21980294, ECO:0000269|PubMed:22146396, ECO:0000269|PubMed:22902367, ECO:0000269|PubMed:9696799}.
                Domain: Ig-like C2-type 2 mediates neurite outgrowth through binding, induction of phosphorylation, and activation of FGFR. {ECO:0000250}.
                Subcellular location: Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}.; Isoform Delta: Cell membrane; Single-pass type I membrane protein.; Isoform Gamma: Secreted.
                Involvement in disease: DISEASE: Ectodermal dysplasia, Margarita Island type (EDMI) [MIM:225060]: An autosomal recessive form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is a syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Non-syndromic orofacial cleft 7 (OFC7) [MIM:225060]: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Note=The disease is caused by mutations affecting the gene represented in this entry.
                Sequence similarity: Belongs to the nectin family. {ECO:0000305}.; Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
                General information above from UniProt

                Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1 is a cell adhesion molecule belonging to the immunoglobulin superfamily that can bind to virion glycoprotein D (gD) to mediate entry of herpes simplex viruses (HSV) and pseudorabies virus (PRV). CD111/Nectin-1/PVRL1 colocalizes with E-cadherin at adherens junctions in epithelial cells. The disruption of cell junctions can result in the redistribution of nectin-1. To determine whether disruption of junctions by calcium depletion influenced the susceptibility of epithelial cells to viral entry, Madin-Darby canine kidney cells expressing endogenous nectin-1 or transfected human nectin-1 were tested for the ability to bind soluble forms of viral gD and to be infected by HSV and PRV, before and after calcium depletion. It has been revealed that binding of HSV and PRV gD was localized to adherens junctions in cells maintained in normal medium but was distributed, along with nectin-1, over the entire cell surface after calcium depletion. Both the binding of gD and the fraction of cells that could be infected by HSV-1 and PRV were enhanced by calcium depletion. Taken together, CD111/Nectin-1/PVRL1 confined to adherens junctions in epithelial cells is not very accessible to virus, whereas dissociation of cell junctions releases nectin-1 to serve more efficiently as an entry recptor.

                CD111/Nectin-1/PVRL1 Alternative Name

                ED4,PRR,HIgR,HV1S,HVEC,OFC7,PRR1,PVRR,CD111,PVRR1,SK-12,CLPED1,nectin-1, [homo-sapiens]
                OFC7,CD111,CLPED1,ED4,HIgR,HVEC,MGC142031,MGC16207,Nectin-1,PRR,PRR1,PVRL1,PVRR,PVRR1,SK-12, [human]
                AI835281,AW549174,Cd111,HIgR,HveC,Nectin-1,PRR,PRR1,Pvrl1, [mouse]
                PRR,HIgR,HveC,PRR1,Cd111,AI835281,AW549174,nectin-1, [mus-musculus]

                CD111/Nectin-1/PVRL1 Related Studies

              • Yoon M, et al. (2002) Disruption of adherens junctions liberates nectin-1 to serve as receptor for herpes simplex virus and pseudorabies virus entry. J Virol. 76(14): 7203-8.
              • Mata M, et al. (2001) HveC (nectin-1) is expressed at high levels in sensory neurons, but not in motor neurons, of the rat peripheral nervous system. J Neurovirol. 7(5): 476-80.
              • Haarr L, et al. (2001) Transcription from the gene encoding the herpesvirus entry receptor nectin-1 (HveC) in nervous tissue of adult mouse. Virology. 287(2): 301-9.
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