CD111 / Nectin-1 / PVRL1 Protein & Antibody (HigR, HVEC, PRR1)

Poliovirus receptor-related 1 (Herpesvirus Ig-like Receptor, Herpes Virus Entry mediator C, Poliovirus Receptor-Related protein 1)

CD111 / Nectin-1 / PVRL1 Products

CD111 / Nectin-1 / PVRL1 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD111/Nectin-1/PVRL1	Human	CD111/Nectin-1/PVRL1/Fc Protein, Recombinant	11611-H02H
CD111/Nectin-1/PVRL1	Human	CD111/Nectin-1/PVRL1 Protein, Recombinant	11611-H08H

  11611-H02H:  Immobilized rh PVRL3 at 1 µg/mL (100 µl/well) can bind recombinant human Nectin-1 with a linear range of 0.156–5 ng/ml. Measured by its binding ability in a functional ELISA.

  11611-H08H:  Immobilized rh PVRL3 at 1 µg/mL (100 µl/well) can bind recombinant human Nectin-1 with a linear range of 6.4–800 ng/ml. Measured by its binding ability in a functional ELISA.

CD111 / Nectin-1 / PVRL1 Antibody

Molecule	Application	Description	Cat. No
Human CD111/Nectin-1/PVRL1	WB, ELISA	CD111/Nectin-1/PVRL1 Antibody, Rabbit PAb	11611-RP01
Human CD111/Nectin-1/PVRL1	WB, ELISA	CD111/Nectin-1/PVRL1 Antibody, Rabbit PAb (Antigen Affinity Purified)	11611-RP02
Human CD111/Nectin-1/PVRL1	WB, ELISA	CD111 / Nectin-1 / PVRL1 Antibody	11611-MM01

CD111 / Nectin-1 / PVRL1 cDNA Clone

Molecule	Species	Description	Cat. No
CD111/Nectin-1/PVRL1	Human	Homo sapiens CD111/Nectin-1/PVRL1 cDNA Clone	HG11611-M
CD111/Nectin-1/PVRL1	Rat	PVRL1 cDNA Clone / ORF Clone	RG80244-G

CD111 / Nectin-1 / PVRL1 Related Areas

Neuroscience>>Synaptic Protein>>CD111/Nectin-1/PVRL1

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>CD111/Nectin-1/PVRL1

Immunology>>Cluster of Differentiation>>CD111/Nectin-1/PVRL1

CD111 / Nectin-1 / PVRL1 Alternative Names

CD111, Nectin-1, PVRL1, HIgR, HVEC, PRR1, PRR, CLPED1, ED4, MGC142031, MGC16207, OFC7, PVRR, PVRR1, SK-12 [Homo sapiens]

Cd111, Nectin-1, Pvrl1, HIgR, HveC, PRR1, PRR, AI835281, AW549174 [Mus musculus]

CD111 / Nectin-1 / PVRL1 Background

Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1 is a cell adhesion molecule belonging to the immunoglobulin superfamily that can bind to virion glycoprotein D (gD) to mediate entry of herpes simplex viruses (HSV) and pseudorabies virus (PRV). CD111/Nectin-1/PVRL1 colocalizes with E-cadherin at adherens junctions in epithelial cells. The disruption of cell junctions can result in the redistribution of nectin-1. To determine whether disruption of junctions by calcium depletion influenced the susceptibility of epithelial cells to viral entry, Madin-Darby canine kidney cells expressing endogenous nectin-1 or transfected human nectin-1 were tested for the ability to bind soluble forms of viral gD and to be infected by HSV and PRV, before and after calcium depletion. It has been revealed that binding of HSV and PRV gD was localized to adherens junctions in cells maintained in normal medium but was distributed, along with nectin-1, over the entire cell surface after calcium depletion. Both the binding of gD and the fraction of cells that could be infected by HSV-1 and PRV were enhanced by calcium depletion. Taken together, CD111/Nectin-1/PVRL1 confined to adherens junctions in epithelial cells is not very accessible to virus, whereas dissociation of cell junctions releases nectin-1 to serve more efficiently as an entry recptor.

CD111 / Nectin-1 / PVRL1 Related Studies

1. Yoon M, et al. (2002) Disruption of adherens junctions liberates nectin-1 to serve as receptor for herpes simplex virus and pseudorabies virus entry. J Virol. 76(14): 7203-8.
2. Mata M, et al. (2001) HveC (nectin-1) is expressed at high levels in sensory neurons, but not in motor neurons, of the rat peripheral nervous system. J Neurovirol. 7(5): 476-80.
3. Haarr L, et al. (2001) Transcription from the gene encoding the herpesvirus entry receptor nectin-1 (HveC) in nervous tissue of adult mouse. Virology. 287(2): 301-9.