CD10 / MME Protein (Neprilysin)

Cluster of Differentiation 10

CD10 / MME Products

CD10 / MME Protein, Recombinant

Molecule	Species	Description	Cat. No
CD10/MME	Human	CD10/Neprilysin/Fc Protein, Recombinant	10805-H01H
CD10/MME	Human	CD10/Neprilysin Protein, Recombinant	10805-H07H
CD10/MME	Human	CD10/Neprilysin Protein, Recombinant	10805-HNCH
CD10/MME	Mouse	CD10/Neprilysin Protein, Recombinant	50218-M07H

  10805-H01H: The specific activity is > 600 pmoles/min/µg. Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK(Dnp)-OH, (R&D Systems, Catalog # ES005).

  10805-H07H: The specific activity is > 3,000 pmoles/min/µg. Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK (Dnp)-OH, (R&D Systems, Catalog # ES005).

  10805-HNCH: The specific activity is > 1,000 pmoles/min/µg. Measured by its ability to cleave the fluorogenic peptide substrate, Mca­-RPPGFSAFK(Dnp)-­OH, (R&D Systems, Catalog # ES005).

CD10 / MME cDNA Clone

Molecule	Species	Description	Cat. No
CD10/MME	Human	Homo sapiens CD10/Neprilysin cDNA Clone	HG10805-M
CD10/MME	Mouse	Mus musculus CD10/Neprilysin cDNA Clone	MG50218-M
CD10/MME	Rat	CD10 / MME cDNA Clone / ORF Clone	RG80288-G

CD10 / MME Related Areas

Cancer>>Angiogenesis>>Other Proteases & Related Molecules in Angiogenesis>>CD10/Neprilysin

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>CD10/Neprilysin

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>>CD10/Neprilysin

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD10/Neprilysin

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Neutrophils>>CD10/Neprilysin

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Migration/Adhesion>>CD10/Neprilysin

CD10 / MME Alternative Names

CD10, MME, Neprilysin, Neutral endopeptidase, NEP, CALLA, DKFZp686O16152, MGC126681, MGC126707 [Homo sapiens]

CD10, Mme, Neprilysin, Neutral endopeptidase, NEP, 6030454K05Rik,C85356,CALLA [Mus musculus]

 

CD10 / MME Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 10 (CD10), also known as Neprilysin and neutral endopeptidase, is a member of the CD system. CD10 is a zinc-dependent metalloprotease enzyme that had function to degrade a number of small secreted peptides such as the amyloid beta peptide. It exist as a membrane-bound protein and have high concentration in kidney and lung tissues. Mutations in the CD10 gene can induce the familial forms of Alzheimer's disease, providing strong evidence for the protein's association with the Alzheimer's disease process. CD10 is also associated with other biochemical processes.

CD10 / MME Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12
4. Dogan, et al. (2000) CD10 and BCL-6 Expression in Paraffin Sections of Normal Lymphoid Tissue and B-Cell Lymphomas. American Journal of Surgical Pathology. 24(6): 846-52.