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Monocyte Marker CD Antigen

Monocytes originate from hematopoietic stem cell precursors called monoblasts in the bone marrow. Monocytes circulate in the bloodstream for about one to three days and then typically move into tissues throughout the body. In the tissues monocytes mature and differentiate into tissue resident macrophages or dendritic cells. Both monocytes and macrophages are phagocytes, acting in both non-specific defense (innate immunity) as well as to help initiate specific defense mechanisms (adaptive immunity) of vertebrate animals. Monocytes and macrophages phagocytose (engulf and then digest) cellular debris and pathogens either as stationary or as mobile cells, and to stimulate lymphocytes and other immune cells to respond to the pathogen.

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Monocyte Marker CD Antigen Background

Monocytes originate from hematopoietic stem cell precursors called monoblasts in the bone marrow. Monocytes circulate in the bloodstream for about one to three days and then typically move into tissues throughout the body. In the tissues monocytes mature and differentiate into tissue resident macrophages or dendritic cells. Both monocytes and macrophages are phagocytes, acting in both non-specific defense (innate immunity) as well as to help initiate specific defense mechanisms (adaptive immunity) of vertebrate animals. Monocytes and macrophages phagocytose (engulf and then digest) cellular debris and pathogens either as stationary or as mobile cells, and to stimulate lymphocytes and other immune cells to respond to the pathogen.

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