All CCR6 reagents are produced in house and quality controlled, including 2 CCR6 Antibody, 39 CCR6 Gene, 3 CCR6 qPCR. All CCR6 reagents are ready to use.
CCR6 antibodies are validated with different applications, which are WB.
CCR6 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CCR6 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Chemokine receptors CCR6 and CCR7 have been reported to play important roles in T cell migration and organ-specific metastasis of various tumors. The expression levels of CCR6 and CCR7 in tumor tissues in patients with lymph node metastases than those without lymph node metastases. CCR6 and CCR7 expressions were also detected in metastatic lymph nodes. CCR6(+) subset of CD4(+) regulatory T cells, a newly characterized subset of Tregs, has been reported to contribute to local immune inhibition. There is a new subset of tumor-resident Tregs, CCR6(+) Tregs, may be dominantly responsible for the immunosuppression in tumor immunity and a potential predictor of the poor prognosis of breast cancer.