CCN4 / WISP1 Protein

WNT1 inducible signaling pathway protein 1

CCN4 / WISP1 Products

CCN4 / WISP1 Protein, Recombinant

Molecule	Species	Description	Cat. No
CCN4/WISP1	Human	CCN4/WISP1 Protein, Recombinant	10442-H08H

  10442-H08H: The ED₅₀ for this effect is typically 10­-25 µg/mL.Measured in a cell proliferation assay using NRK-49F rat fibroblasts. (Xu, L. et al., 2000, Gene and Dev. 14: 585.)

CCN4 / WISP1 cDNA Clone

Molecule	Species	Description	Cat. No
CCN4/WISP1	Human	Homo sapiens CCN4/WISP1 cDNA Clone(NM_003882.2)	HG10442-M

CCN4 / WISP1 Alternative Names

CCN4, WISP1, WISP1c, WISP1i, WISP1tc [Homo sapiens]

Wisp1, AW146261, Elm1 [Mus musculus]

CCN4 / WISP1 Related Areas

Cancer>>Angiogenesis>>ECM Molecules in Angiogenesis>>CCN4/WISP1

Cancer>>Growth Factor & Receptor>>IGF System>>CCN4/WISP1

Cancer>>Growth Factor & Receptor>>Other>>CCN4/WISP1

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>CCN4/WISP1

CCN4 / WISP1 Related Products

Protein Products

Molecule	Species	Description
CCN3/NOV/IGFBP9	Human	CCN3/NOV/IGFBP9 Protein, Recombinant
IGF1R/CD221	Human	IGF1R/CD221 Protein, Recombinant
IGFBP3	Human	IGFBP3 Protein, Recombinant
IGFBP4	Human	IGFBP4 Protein, Recombinant
IGFBP4	Mouse	IGFBP4 Protein, Recombinant
Insulin Receptor/CD220	Human	Insulin Receptor/CD220 Protein, Recombinant
Insulin Receptor/CD220	Human	Insulin Receptor/CD220 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human CCN3/NOV/IGFBP9	WB, ELISA	Rabbit Polyclonal Antibody
Human IGF1R/CD221	WB	Mouse Monoclonal Antibody
Human IGF1R/CD221	WB	Mouse Monoclonal Antibody
Human IGF1R/CD221	ELISA	Mouse Monoclonal Antibody
Human IGF1R/CD221	WB, ELISA	Rabbit Monoclonal Antibody
Human IGF1R/CD221	ELISA	Rabbit Polyclonal Antibody
Human IGF1R/CD221	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human Insulin Receptor/CD220	WB, ELISA	Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule	Species	Description
CCN3	Human	Homo sapiens CCN3 cDNA Clone(NM_002514.3)
IGF1R /CD221	Human	Homo sapiens IGF1R /CD221 cDNA Clone(NM_000875.3)
IGFBP3	Human	Homo sapiens IGFBP3 cDNA Clone(NM_000598.4)
IGFBP4	Human	Homo sapiens IGFBP4 cDNA Clone(NM_001552.2)
IGFBP5	Human	Homo sapiens IGFBP5 cDNA Clone(NM_000599.3)

CCN4 Background

CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: a IGFBP (insulin-like growthfactor-binding) domain, a von Willebrand type C domain, a thrombospondin domain and a C-terminal cysteine -knot domain. WISP1 is a putative downstream effector of the Wnt/Frizzled pathway that mediates diversedevelopmental processes, was identified as an oncogene regulated by the Wnt-1-beta-catenin pathway. Thus may contributes to Wnt-1-mediated tumorigenesis and malignance. Expression of WISP1 in some cells results in transformation and tumorigenesis. WISP1 acts to block cell death at a late stage in the p53-mediated apoptosis pathway. It was reported that WISP1 interacts with sulfated glycoconjugates, decorin and biglycan in the ECM of connective tissue, and possibly prevents their inhibitory activity in tumor cell proliferation.

CCN4 Related Studies

1. Su F, et al. (2002) WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev. 16(1): 46-57.
2. Yanagita T, et al. (2007) Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes. FEBS J. 274(7): 1655-65.
3. Wang H, et al. (2009) Nitric oxide increases Wnt-induced secreted protein-1 (WISP-1/CCN4) expression and function in colitis. J Mol Med. 87(4): 435-45.
4. Venkatachalam K, et al. (2009) WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death. J Biol Chem. 284(21): 14414-27.